Recent Advancements in the Discovery of MDM2/MDM2-p53 Interaction Inhibitors for the Treatment of Cancer

dc.contributor.authorBhatia, Neha
dc.contributor.authorKhator, Rakesh
dc.contributor.authorKulkarni, Swanand
dc.contributor.authorSingh, Yogesh
dc.contributor.authorKumar, Pradeep
dc.contributor.authorThareja, Suresh
dc.date.accessioned2024-01-21T10:38:28Z
dc.date.accessioned2024-08-13T12:05:25Z
dc.date.available2024-01-21T10:38:28Z
dc.date.available2024-08-13T12:05:25Z
dc.date.issued2022-11-16T00:00:00
dc.description.abstractDiscovery of MDM2 and MDM2-p53 interaction inhibitors changed the direction of anticancer research as it is involved in about 50% of cancer cases globally. Not on-ly the inhibition of MDM2 but also its interaction with p53 proved to be an effective strategy in anticancer drug design and development. Various molecules of natural as well as synthetic origin have been reported to possess excellent MDM2 inhibitory potential. The present review discusses the pathophysiology of the MDM2-p53 interaction loop and MDM2/MDM2-p53 interaction inhibitors from literature covering recent patents. Focus has also been put on characteristic features of the active site of the target and its desired interactions with the currently FDA-approved inhibitor. The designing approach of previ-ously reported MDM2/MDM2-p53 interaction inhibitors, their SAR studies, in silico studies, and the biological efficacy of various inhibitors from natural as well as synthetic origins are also elaborated. An attempt is made to cover recently patented MDM2/MD-M2-p53 interaction inhibitors. � 2023 Bentham Science Publishers.en_US
dc.identifier.doi10.2174/0929867330666221114103924
dc.identifier.issn9298673
dc.identifier.urihttps://kr.cup.edu.in/handle/32116/3581
dc.identifier.urlhttps://www.eurekaselect.com/210872/article
dc.language.isoen_USen_US
dc.publisherBentham Science Publishersen_US
dc.subjectbiological efficacyen_US
dc.subjectcanceren_US
dc.subjectMDM2-p53 inhibitoren_US
dc.subjectMurine double minute 2 (MDM2)en_US
dc.subjectnutlinen_US
dc.subjectp53en_US
dc.titleRecent Advancements in the Discovery of MDM2/MDM2-p53 Interaction Inhibitors for the Treatment of Canceren_US
dc.title.journalCurrent Medicinal Chemistryen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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