Mitochondrial miRNA as epigenomic signatures: Visualizing aging-associated heart diseases through a new lens

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dc.contributor.authorBhatti, Jasvinder Singh
dc.contributor.authorKhullar, Naina
dc.contributor.authorVijayvergiya, Rajesh
dc.contributor.authorNavik, Umashanker
dc.contributor.authorBhatti, Gurjit Kaur
dc.contributor.authorReddy, P. Hemachandra
dc.date.accessioned2024-01-21T10:54:11Z
dc.date.accessioned2024-08-14T07:40:55Z
dc.date.available2024-01-21T10:54:11Z
dc.date.available2024-08-14T07:40:55Z
dc.date.issued2023-02-11T00:00:00
dc.description.abstractAging bears many hard knocks, but heart disorders earn a particular allusion, being the most widespread. Cardiovascular diseases (CVDs) are becoming the biggest concern to mankind due to sundry health conditions directly or indirectly related to heart-linked abnormalities. Scientists know that mitochondria play a critical role in the pathophysiology of cardiac diseases. Both environment and genetics play an essential role in modulating and controlling mitochondrial functions. Even a minor abnormality may prove detrimental to heart function. Advanced age combined with an unhealthy lifestyle can cause most cardiomyocytes to be replaced by fibrotic tissue which upsets the conducting system and leads to arrhythmias. An aging heart encounters far more heart-associated comorbidities than a young heart. Many state-of-the-art technologies and procedures are already being used to prevent and treat heart attacks worldwide. However, it remains a mystery when this heart bomb would explode because it lacks an alarm. This calls for a novel and effective strategy for timely diagnosis and a sure-fire treatment. This review article provides a comprehensive overture of prospective potentials of mitochondrial miRNAs that predict complicated and interconnected pathways concerning heart ailments and signature compilations of relevant miRNAs as biomarkers to plot the role of miRNAs in epigenomics. This article suggests that analysis of DNA methylation patterns in age-associated heart diseases may determine age-impelled biomarkers of heart disease. � 2023 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.arr.2023.101882
dc.identifier.issn15681637
dc.identifier.urihttp://10.2.3.109/handle/32116/4240
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S1568163723000417
dc.language.isoen_USen_US
dc.publisherElsevier Ireland Ltden_US
dc.subjectCardiovascular diseasesen_US
dc.subjectEpigenomicsen_US
dc.subjectFibrosisen_US
dc.subjectMitochondrial miRNAen_US
dc.titleMitochondrial miRNA as epigenomic signatures: Visualizing aging-associated heart diseases through a new lensen_US
dc.title.journalAgeing Research Reviewsen_US
dc.typeShort surveyen_US
dc.type.accesstypeClosed Accessen_US

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Human Genetics And Molecular Medicine - Research Publications