Tinospora cordifolia: a potential neuroprotective agent against various neurodegenerative diseases

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dc.contributor.authorSingh, Randeep
dc.contributor.authorBhattacharyya, Chinmoyee
dc.contributor.authorPrashar, Vikash
dc.contributor.authorArora, Tania
dc.contributor.authorSharma, Arti
dc.contributor.authorChangotra, Harish
dc.contributor.authorParkash, Jyoti
dc.date.accessioned2024-01-21T10:34:44Z
dc.date.accessioned2024-08-13T11:13:25Z
dc.date.available2024-01-21T10:34:44Z
dc.date.available2024-08-13T11:13:25Z
dc.date.issued2023-09-19T00:00:00
dc.description.abstractIntroduction: Neurodegenerative diseases negatively affect the various neuronal populations of the central nervous system (CNS). Moreover, conventional treatment strategies are inefficient and have considerable side effects. Since Ayurveda has always been considered an effective alternative to synthetic drugs, Tinospora cordifolia, an age-old renowned herb in Ayurveda with great medicinal importance, is drawing the attention of researchers. The effect of the crude extract of T. cordifolia and its constituents in alleviating neurodegenerative diseases has been reported previously and recently. Methods: This study followed thorough research on scientific databases like PubMed, Google Scholar, and ScienceDirect regarding the practical implications of T. cordifolia extracts and compounds in alleviating neurodegeneration. Various search terms like �neurodegenerative diseases�, �T. cordifolia and neurodegeneration�, �signalling mechanisms of neurodegeneration�, and �neuroprotective effect of T. cordifolia� have been used. Results: Several in vitro studies have suggested that T. cordifolia extracts and compounds can improve memory, cognition, and learning deteriorated by various neurodegenerative diseases. They also enhance the potential of the antioxidant system by restoring Glutathione (GSH) and Superoxide dismutase (SOD) levels and scavenging the free radicals that cause neuronal oxidative stress and neurodegeneration. Conclusion: This review article summarises the various aspects of T. cordifolia against different neurodegenerative diseases and its future potential therapeutic values. It also emphasises the need to investigate other compounds present in T. cordifolia. Limitations and future prospects: Exploring anti-oxidative, anti-inflammatory, and neuroprotective properties proved T. cordifolia to be a life saviour. Despite this, extensive clinical and pharmacological studies are required to evaluate the precise dosage and formulation of its constituents. � 2023 Elsevier GmbHen_US
dc.identifier.doi10.1016/j.hermed.2023.100775
dc.identifier.issn22108033
dc.identifier.urihttp://10.2.3.109/handle/32116/3318
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S2210803323001537
dc.language.isoen_USen_US
dc.publisherElsevier GmbHen_US
dc.subjectAntioxidanten_US
dc.subjectAyurvedaen_US
dc.subjectNeurodegenerativeen_US
dc.subjectNeuroprotectiveen_US
dc.subjectTinospora cordifoliaen_US
dc.titleTinospora cordifolia: a potential neuroprotective agent against various neurodegenerative diseasesen_US
dc.title.journalJournal of Herbal Medicineen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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