2-(2-Arylphenyl) benzoxazole As a Novel Anti-Inflammatory Scaffold: Synthesis and Biological Evaluation

dc.contributor.authorSeth, Kapileswar
dc.contributor.authorGarg, Sanjeev K.
dc.contributor.authorKumar, Raj
dc.contributor.authorPurohit, Priyank
dc.contributor.authorMeena, Vachan S.
dc.contributor.authorGoyal, Rohit
dc.contributor.authorBanerjee, Uttam C.
dc.contributor.authorChakraborti, Asit K.
dc.date.accessioned2019-04-29T10:37:22Z
dc.date.accessioned2024-08-13T12:04:58Z
dc.date.available2019-04-29T10:37:22Z
dc.date.available2024-08-13T12:04:58Z
dc.date.issued2014
dc.description.abstractThe 2-(2-arylphenyl)benzoxazole moiety has been found to be a new and selective ligand for the enzyme cyclooxygenase-2 (COX-2). The 2-(2-arylphenyl)benzoxazoles 3a−m have been synthesized by Suzuki reaction of 2-(2-bromophenyl)benzoxazole. Further synthetic manipulation of 3f and 3i led to 3o and 3n, respectively. The compounds 3g, 3n, and 3o selectively inhibited COX-2 with selectivity index of 3n much better than that of the COX-2 selective NSAID celecoxib. The in vivo anti-inflammatory potency of 3g and 3n is comparable to that of celecoxib and the nonselective NSAID diclofenac at two different doses, and 3o showed better potency compared to these clinically used NSAIDs.en_US
dc.identifier.citationSeth, Kapileswar., Garg, Sanjeev K. and Kumar, Raj et. al. (2014) 2-(2-Arylphenyl) benzoxazole As a Novel Anti-Inflammatory Scaffold: Synthesis and Biological Evaluation. ACSMedicinal Chemistry Letters. Vol. 5, PP. 512�516en_US
dc.identifier.doi10.1021/ml400500e
dc.identifier.issn1948-5875
dc.identifier.urihttps://kr.cup.edu.in/handle/32116/2333
dc.identifier.urlhttps://pubs.acs.org/doi/abs/10.1021/ml400500e
dc.language.isoenen_US
dc.publisherACS publicationsen_US
dc.subject2-(2-Arylphenyl)benzoxazoles; 3D QSAR; cyclooxygenase-2 selective; in vivo potency; novel anti-inflammatory scaffolden_US
dc.title2-(2-Arylphenyl) benzoxazole As a Novel Anti-Inflammatory Scaffold: Synthesis and Biological Evaluationen_US
dc.title.journalACSMedicinal Chemistry Lettersen_US
dc.typeArticleen_US
dc.type.accesstypeOpen Accessen_US

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