Recent Advancement of Polymersomes as Drug Delivery Carrier

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dc.contributor.authorSingh, Kuldeep
dc.contributor.authorBiharee, Avadh
dc.contributor.authorVyas, Amber
dc.contributor.authorThareja, Suresh
dc.contributor.authorJain, Akhlesh Kumar
dc.date.accessioned2024-01-21T10:38:21Z
dc.date.accessioned2024-08-13T12:05:16Z
dc.date.available2024-01-21T10:38:21Z
dc.date.available2024-08-13T12:05:16Z
dc.date.issued2022-04-14T00:00:00
dc.description.abstractBackground: Biomedical applications of polymersomes have been explored, including drug and gene delivery, insulin delivery, hemoglobin delivery, the delivery of anticancer agents, and various diagnostic purposes. Objectives: Polymersomes, which are self-assembled amphiphilic block copolymers, have received a lot of at-tention in drug delivery approaches. This review represents the methods of preparation of polymersomes, including thin-film rehydration, electroformation, double emulsion, gel-assisted rehydration, PAPYRUS method, and solvent injection methods, including various therapeutic applications of polymersomes. Methods: Data was searched from PubMed, Google Scholar, and Science Direct through searching of the following keywords: Polymersomes, methods of preparation, amphiphilic block copolymers, anticancer drug delivery Results: Polymersomes provide both hydrophilic and hydrophobic drug delivery to a targeted site, increasing the formulation's stability and reducing the cytotoxic side effects of drugs. Conclusion: Polymersomes have the potential to be used in a variety of biological applications, including drug and gene delivery, insulin delivery, hemoglobin delivery, delivery of anticancer agents, as well as in various diagnostic purposes. Recently, polymersomes have been used more frequently because of their stability, reducing the encapsulated drug's leakage, site-specific drug delivery, and increasing the bioavailability of the drugs and different diagnostic purposes. The liposomes encapsulate only hydrophilic drugs, but polymersomes encapsulate both hydrophilic and hydrophobic drugs in their cores. � 2022 Bentham Science Publishers.en_US
dc.identifier.doi10.2174/1381612828666220412103552
dc.identifier.issn13816128
dc.identifier.urihttp://10.2.3.109/handle/32116/3540
dc.identifier.urlhttps://www.eurekaselect.com/203440/article
dc.language.isoen_USen_US
dc.publisherBentham Science Publishersen_US
dc.subjectanticanceren_US
dc.subjectblock copolymeren_US
dc.subjectdouble emulsionen_US
dc.subjectdrug deliveryen_US
dc.subjectelectroformationen_US
dc.subjectmethod of preparationen_US
dc.subjectPAPYRUSen_US
dc.subjectPolymersomesen_US
dc.subjectsolvent injectionen_US
dc.subjectthin-film rehydrationen_US
dc.titleRecent Advancement of Polymersomes as Drug Delivery Carrieren_US
dc.title.journalCurrent Pharmaceutical Designen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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Pharmaceutical Sciences and Natural Products - Research Publications