Efficient approach towards the polysubstituted 4h-pyran hybrid quinolone derivatives and subsequent copper-catalyzed hydroxylation of haloarenes

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2021-03-16T00:00:00

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Japan Institute of Heterocyclic Chemistry

Abstract

A proficient and feasible approach towards polysubstituted quinolone conjugated 4H-pyrans has been elucidated. The illustrated phenomenon concern with the base-mediated multicomponent reaction and subsequent copper-catalyzed hydroxylation of C-X bond emerging in an amide functionality. The developed reaction conditions showcased considerable substrate scope and functional group tolerance by giving the desired products in good yields. � 2021 Japan Institute of Heterocyclic Chemistry. All rights reserved.

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