Targeting Mitochondria as a Novel Disease-Modifying Therapeutic Strategy in Cancer

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dc.contributor.authorBhatti, Gurjit Kaur
dc.contributor.authorPahwa, Paras
dc.contributor.authorGupta, Anshika
dc.contributor.authorSidhu, Inderpal Singh
dc.contributor.authorNavik, Uma Shanker
dc.contributor.authorReddy, P. Hemachandra
dc.contributor.authorBhatti, Jasvinder Singh
dc.date.accessioned2024-01-21T10:55:06Z
dc.date.accessioned2024-08-14T07:44:21Z
dc.date.available2024-01-21T10:55:06Z
dc.date.available2024-08-14T07:44:21Z
dc.date.issued2022-09-28T00:00:00
dc.description.abstractMitochondria are essential for the metabolism of energy, regulation of apoptosis, and cell signaling. Overproduction of reactive oxidation species (ROS) in mitochondria is one of the indications of cancer cells. Moreover, this boosts the proliferation of cancerous cells by causing genomic instability and altering gene expressions. Mitochondrial and nuclear DNA mutations caused by oxidative damage impair the mechanism of oxidative phosphorylation and can lead to more mitochondrial ROS output, genome instability, and cancer development. The classic approach to target mitochondria of cancerous cells with novel targeted therapeutics helps in targeting the mitochondrial apoptotic proteins and changing energy metabolism. A key benefit of selective drug delivery is that it reduces the drug�s toxicity and increases specificity. A better understanding of the mitochondrial role in tumor growth will help design more therapeutic agents with better selectivity. � Springer Nature Singapore Pte Ltd. 2022.en_US
dc.identifier.doi10.1007/978-981-16-5422-0_175
dc.identifier.isbn9789811654220
dc.identifier.isbn9789811654213
dc.identifier.urihttp://10.2.3.109/handle/32116/4338
dc.identifier.urlhttps://link.springer.com/10.1007/978-981-16-5422-0_175
dc.language.isoen_USen_US
dc.publisherSpringer Singaporeen_US
dc.subjectBioenergetic therapyen_US
dc.subjectCanceren_US
dc.subjectMitochondriaen_US
dc.subjectMitochondrial medicineen_US
dc.subjectROSen_US
dc.subjectTargeted drug deliveryen_US
dc.titleTargeting Mitochondria as a Novel Disease-Modifying Therapeutic Strategy in Canceren_US
dc.title.journalHandbook of Oxidative Stress in Cancer: Therapeutic Aspects: Volume 1en_US
dc.typeBook chapteren_US
dc.type.accesstypeClosed Accessen_US

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