Galangin: A metabolite that suppresses anti-neoplastic activities through modulation of oncogenic targets

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dc.contributor.authorTuli, Hardeep Singh
dc.contributor.authorSak, Katrin
dc.contributor.authorAdhikary, Shubham
dc.contributor.authorKaur, Ginpreet
dc.contributor.authorAggarwal, Diwakar
dc.contributor.authorKaur, Jagjit
dc.contributor.authorKumar, Manoj
dc.contributor.authorParashar, Nidarshana Chaturvedi
dc.contributor.authorParashar, Gaurav
dc.contributor.authorSharma, Uttam
dc.contributor.authorJain, Aklank
dc.date.accessioned2024-01-21T10:44:38Z
dc.date.accessioned2024-08-13T13:21:43Z
dc.date.available2024-01-21T10:44:38Z
dc.date.available2024-08-13T13:21:43Z
dc.date.issued2021-12-14T00:00:00
dc.description.abstractWith the dramatic increase in cancer incidence all over the world in the last decades, studies on identifying novel efficient anti-cancer agents have been intensified. Historically, natural products have represented one of the most important sources of new lead compounds with a wide range of biological activities. In this article, the multifaceted anti-cancer action of propolis-derived flavonoid, galangin, is presented, discussing its antioxidant, anti-inflammatory, antiproliferative, pro-apoptotic, anti-angiogenic, and anti-metastatic effects in various cancer cells. In addition, co-effects with standard chemotherapeutic drugs as well as other natural compounds are also under discussion, besides highlighting modern nanotechnological advancements for overcoming the low bioavailability issue characteristic of galangin. Although further studies are needed for confirming the anti-cancer potential of galangin in vivo malignant systems, exploring this natural compound might open new perspectives in molecular oncology. � 2021 by the Society for Experimental Biology and Medicine.en_US
dc.identifier.doi10.1177/15353702211062510
dc.identifier.issn15353702
dc.identifier.urihttp://10.2.3.109/handle/32116/3812
dc.identifier.urlhttp://journals.sagepub.com/doi/10.1177/15353702211062510
dc.language.isoen_USen_US
dc.publisherSAGE Publications Inc.en_US
dc.subjectabsorptionen_US
dc.subjectanti-canceren_US
dc.subjectepigeneticsen_US
dc.subjectGalanginen_US
dc.subjectnano-deliveryen_US
dc.subjectsynergisticen_US
dc.titleGalangin: A metabolite that suppresses anti-neoplastic activities through modulation of oncogenic targetsen_US
dc.title.journalExperimental Biology and Medicineen_US
dc.typeReviewen_US
dc.type.accesstypeOpen Accessen_US

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