Neurodegenerative diseases and brain delivery of therapeutics: Bridging the gap using dendrimers

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dc.contributor.authorKaur, Amandeep
dc.contributor.authorSingh, Navneet
dc.contributor.authorKaur, Harmanpreet
dc.contributor.authorKakoty, Violina
dc.contributor.authorSharma, Deep Shikha
dc.contributor.authorKhursheed, Rubiya
dc.contributor.authorBabu, Molakpogu Ravindra
dc.contributor.authorHarish, Vancha
dc.contributor.authorGupta, Gaurav
dc.contributor.authorGulati, Monica
dc.contributor.authorKumar, Puneet
dc.contributor.authorDureja, Harish
dc.contributor.authorAlharthi, Nahed S.
dc.contributor.authorKhan, Farhan R.
dc.contributor.authorRehman, Zia ur
dc.contributor.authorHakami, Mohammed Ageeli
dc.contributor.authorPatel, Mrunali
dc.contributor.authorPatel, Rashmin
dc.contributor.authorZandi, Milad
dc.contributor.authorVishwas, Sukriti
dc.contributor.authorDua, Kamal
dc.contributor.authorSingh, Sachin Kumar
dc.date.accessioned2024-01-21T10:55:17Z
dc.date.accessioned2024-08-14T07:44:15Z
dc.date.available2024-01-21T10:55:17Z
dc.date.available2024-08-14T07:44:15Z
dc.date.issued2023-08-26T00:00:00
dc.description.abstractNeurodegenerative diseases (NDs) continue to burden human lives and economic conditions. They continue to challenge the healthcare system due to the associated physiological barriers. Traditional treatment approaches are associated with symptomatic relief and are ineffective in the long run. Dendrimers stand out amongst other nanocarriers due to ease of surface modifications, internal encapsulation, and nanoscale uniformity of the molecule. Moreover, their internal core can encapsulate drug through electrostatic interactions. These are stable carriers in the nanometer size range. These either act as therapeutic agents per se or deliver the target drug across the blood-brain barrier while minimizing toxicity. Emerging as a promising non-invasive approach, they demonstrate the capability to interfere with in-vivo protein aggregation, typically associated with neurodegeneration. They assist via exerting various neuroprotective roles, such as in oxidative stress, neuroinflammation, inhibiting certain biochemical parameters, altering protein misfolding and aggregation, etc. However, certain limitations are associated with their elimination and cytotoxicity. The investigation revealed the masking of exposed cationic surfaces of dendrimers with inert substances, such as polyethylene glycol to limit their cytotoxicity. This review describes the incidences and pathophysiology of several NDs, properties, and methods of dendrimer synthesis, followed by various research to explore dendrimers potential to treat NDs. � 2023 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.jddst.2023.104868
dc.identifier.issn17732247
dc.identifier.urihttp://10.2.3.109/handle/32116/4391
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S1773224723007207
dc.language.isoen_USen_US
dc.publisherEditions de Santeen_US
dc.subjectBlood brain barrieren_US
dc.subjectDendrimersen_US
dc.subjectDrug deliveryen_US
dc.subjectNeurodegenerative diseasesen_US
dc.subjectNeuroprotective effectsen_US
dc.titleNeurodegenerative diseases and brain delivery of therapeutics: Bridging the gap using dendrimersen_US
dc.title.journalJournal of Drug Delivery Science and Technologyen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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