Microwave-assisted synthesis of pyrazolo[1,5-c]quinazolines and their derivatives

Abstract

Microwave accelerated and expedited cyclocondensation reactions of 2-(3-aryl-1H-pyrazol-5-yl)anilines (4) with diverse aryl aldehydes/triethyl orthoformate in water/MeCN (route D) and internal cyclocondensation and aromatization of 5-(2-aminophenyl)-4,5-dihydro-3-arylpyrazole-1-carbaldehyde (7) under MeOH (route E) for the synthesis of a series of pyrazolo[1,5-c]quinazolines and their derivatives (1a–1q) are reported.