Emerging Role of Migration and Invasion Enhancer 1 (MIEN1) in Cancer Progression and Metastasis

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dc.contributor.authorKushwaha, P.P
dc.contributor.authorGupta, S
dc.contributor.authorSingh, A.K
dc.contributor.authorKumar, S.
dc.date.accessioned2019-10-23T04:42:44Z
dc.date.accessioned2024-08-13T10:34:45Z
dc.date.available2019-10-23T04:42:44Z
dc.date.available2024-08-13T10:34:45Z
dc.date.issued2019
dc.description.abstractTumor metastasis is a sequential event accounting for numerous cancer-related fatalities worldwide. The process of metastasis serially involves invasion, intravasation, extravasation, and tumor growth at the secondary site. Migration and invasion enhancer 1 (MIEN1) is a membrane associated protein overexpressed in various human cancers. Biological activity of MIEN1 is driven by geranylgeranyltransferase-I mediated prenylation at CAAX motif and methylation of the prenylated protein that anchors MIEN1 into the cellular membrane. Post-translationally modified MIEN1 interacts with Syk kinase and Annexin A2 protein; polymerizes G-actin and stabilizes F-actin filament; induces focal adhesion kinase phosphorylation and decrease cofilin phosphorylation implicated in both invasion and metastasis of different cancer types. In the present review, we discuss the structure, function, and involvement of MIEN1 in cancer progression. We also highlight the future prospects of MIEN1 as an emerging molecule and novel target in cancer cell invasion and metastasis.en_US
dc.identifier.citationKushwaha, P.P; Gupta, S; Singh, A.K. et. Al. (2019) Emerging Role of Migration and Invasion Enhancer 1 (MIEN1) in Cancer Progression and Metastasis. Frontiers in Oncology. Vol. 9.en_US
dc.identifier.doi10.3389/fonc.2019.00868
dc.identifier.issn2234943X
dc.identifier.urihttp://10.2.3.109/handle/32116/2485
dc.identifier.urlhttps://www.frontiersin.org/articles/10.3389/fonc.2019.00868/full
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.subjectcanceren_US
dc.subjectinvasionen_US
dc.subjectmetastasisen_US
dc.subjectMIEN1en_US
dc.subjectposttranslational modificationen_US
dc.titleEmerging Role of Migration and Invasion Enhancer 1 (MIEN1) in Cancer Progression and Metastasisen_US
dc.title.journalFrontiers in Oncologyen_US
dc.typeReviewen_US
dc.type.accesstypeOpen Accessen_US

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