Daidzein Attenuates Ovariectomy-Induced Cognitive Deficits by Improving Cortical Endothelial Function in Rats

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dc.contributor.authorJaiswal, Salok
dc.contributor.authorGoyal, Ahsas
dc.contributor.authorGarabadu, Debapriya
dc.date.accessioned2024-01-21T10:55:16Z
dc.date.accessioned2024-08-14T07:44:15Z
dc.date.available2024-01-21T10:55:16Z
dc.date.available2024-08-14T07:44:15Z
dc.date.issued2023-07-17T00:00:00
dc.description.abstractThere have been reports of decreased vascular activity in memory-sensitive brain areas, which is thought to be a different approach to managing cognitive deficiencies in females with estrogen insufficiency. Daidzein, a plant-derived phytoestrogen, facilitates cerebral blood flow in normal animals and also improves vascular activity in the peripheral tissues of the ovariectomized animal. However, its neuroprotective activity in vascular function has not yet been established in ovariectomized animals. Hence, the present study explored the caveolin-1/eNOS/VEGF-mediated signaling in the anti-amnesic ability of daidzein in ovariectomized rats. On day 5 of the Morris water maze experiment, female rats with bilateral ovariectomy displayed amnesia as measured by an increase in both escape latency and time spent in the targeted quadrant. Further, ovariectomy reduced blood flow and the level of expression of vascular endothelial growth factor in rat cortical tissues. In addition, ovariectomy diminished the acetylcholine level, increased the acetylcholinesterase activity, and increased oxidative stress in rat cortical tissues. Daidzein attenuated ovariectomy-induced alterations in behavioral, vascular, cholinergic, and oxidative stress in the animals. These beneficial effects of daidzein were abolished with N-nitro-l-arginine methylester (L-NAME), which inhibits endothelial nitric oxide synthase, in the ovariectomized rat model. These observations emphasize the fact that daidzein potentially exerts anti-amnesic activity perhaps through the caveolin-1/eNOS/VEGF-mediated signaling pathway in ovariectomy-induced cognitive-deficit rats. Therefore, daidzein holds the potential as a therapeutic option for the treatment of cognitive deficits in postmenopausal women. Graphical Abstract: [Figure not available: see fulltext.]. � 2023, The Author(s) under exclusive licence to Sociedade Brasileira de Farmacognosia.en_US
dc.identifier.doi10.1007/s43450-023-00425-3
dc.identifier.issn1981528X
dc.identifier.urihttp://10.2.3.109/handle/32116/4389
dc.identifier.urlhttps://link.springer.com/10.1007/s43450-023-00425-3
dc.language.isoen_USen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.subjectAcetylcholineen_US
dc.subjectCortexen_US
dc.subjectEstrogenen_US
dc.subjectIsoflavoneen_US
dc.subjectMemoryen_US
dc.subjectVascular functionen_US
dc.titleDaidzein Attenuates Ovariectomy-Induced Cognitive Deficits by Improving Cortical Endothelial Function in Ratsen_US
dc.title.journalRevista Brasileira de Farmacognosiaen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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