Immunodominant conserved moieties on spike protein of SARS-CoV-2 renders virulence factor for the design of epitope-based peptide vaccines

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dc.contributor.authorMohapatra, Subhashree
dc.contributor.authorKumar, Santosh
dc.contributor.authorKumar, Shashank
dc.contributor.authorSingh, Atul Kumar
dc.contributor.authorNayak, Bismita
dc.date.accessioned2024-01-16T14:23:32Z
dc.date.accessioned2024-08-13T10:34:23Z
dc.date.available2024-01-16T14:23:32Z
dc.date.available2024-08-13T10:34:23Z
dc.date.issued2023-11-23T00:00:00
dc.description.abstractThe outbreak of novel SARS-CoV-2 virion has wreaked havoc with a high prevalence of respiratory illness and high transmission due to a vague understanding of the viral antigenicity, augmenting the dire challenge to public health globally. This viral member necessitates the expansion of diagnostic and therapeutic tools to track its transmission and confront it through vaccine development. Therefore, prophylactic strategies are mandatory. Virulent spike proteins can be the most desirable candidate for the computational design of vaccines targeting SARS-CoV-2, followed by the meteoric development of immune epitopes. Spike protein was characterized using existing bioinformatics tools with a unique roadmap related to the immunological profile of SARS-CoV-2 to predict immunogenic virulence epitopes based on antigenicity, allergenicity, toxicity, immunogenicity, and population coverage. Applying in silico approaches, a set of twenty-four B lymphocyte-based epitopes and forty-six T lymphocyte-based epitopes were selected. The predicted epitopes were evaluated for their intrinsic properties. The physico-chemical characterization of epitopes qualifies them for further in vitro and in vivo analysis and pre-requisite vaccine development. This study presents a set of screened epitopes that bind to HLA-specific allelic proteins and can be employed for designing a peptide vaccine construct against SARS-CoV-2 that will confer vaccine-induced protective immunity due to its structural stability. � 2023, The Author(s), under exclusive licence to Indian Virological Society.en_US
dc.identifier.doi10.1007/s13337-023-00852-9
dc.identifier.issn23473584
dc.identifier.urihttps://doi.org/10.1007/s13337-023-00852-9
dc.identifier.urihttp://10.2.3.109/handle/32116/2957
dc.language.isoen_USen_US
dc.publisherSpringeren_US
dc.subjectCOVID-19en_US
dc.subjectEpidemicen_US
dc.subjectEpitopesen_US
dc.subjectIn silico analysisen_US
dc.subjectSARS-CoV-2en_US
dc.subjectVaccineen_US
dc.titleImmunodominant conserved moieties on spike protein of SARS-CoV-2 renders virulence factor for the design of epitope-based peptide vaccinesen_US
dc.title.journalVirusDiseaseen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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Biochemistry And Microbial Sciences - Research Publications