Role of miRNAs in diabetic neuropathy: mechanisms and possible interventions

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dc.contributor.authorKaur, Prabhsimran
dc.contributor.authorKotru, Sushil
dc.contributor.authorSingh, Sandeep
dc.contributor.authorMunshi, Anjana
dc.date.accessioned2024-01-21T10:54:03Z
dc.date.accessioned2024-08-14T07:40:49Z
dc.date.available2024-01-21T10:54:03Z
dc.date.available2024-08-14T07:40:49Z
dc.date.issued2022-01-13T00:00:00
dc.description.abstractAccelerating cases of diabetes worldwide have given rise to higher incidences of diabetic complications. MiRNAs, a much-explored class of non-coding RNAs, play a significant role in the pathogenesis of diabetes mellitus by affecting insulin release, ?-cell proliferation, and dysfunction. Besides, disrupted miRNAs contribute to various complications, diabetic retinopathy, nephropathy, and neuropathy as well as severe conditions like diabetic foot. MiRNAs regulate various processes involved in diabetic complications like angiogenesis, vascularization, inflammations, and various signaling pathways like PI3K, MAPK, SMAD, and NF-KB signaling pathways. Diabetic neuropathy is the most common diabetic complication, characterized mainly by pain and numbness, especially in the legs and feet. MiRNAs implicated in diabetic neuropathy include mir-9, mir-106a, mir-146a, mir-182, miR-23a and b, miR-34a, and miR-503. The diabetic foot is the most common diabetic neuropathy, often leading to amputations. Mir-203, miR-23c, miR-145, miR-29b and c, miR-126, miR-23a and b, miR-503, and miR-34a are associated with diabetic foot. This review has been compiled to summarize miRNA involved in initiation, progression, and miRNAs affecting various signaling pathways involved in diabetic neuropathy including the diabetic foot. Besides, potential applications of miRNAs as biomarkers and therapeutic targets in this microvascular complication will also be discussed. � 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.en_US
dc.identifier.doi10.1007/s12035-021-02662-w
dc.identifier.issn8937648
dc.identifier.urihttp://10.2.3.109/handle/32116/4200
dc.identifier.urlhttps://link.springer.com/10.1007/s12035-021-02662-w
dc.language.isoen_USen_US
dc.publisherSpringeren_US
dc.subjectDiabetic complicationsen_US
dc.subjectDiabetic footen_US
dc.subjectDiabetic neuropathyen_US
dc.subjectMicrovascular complicationsen_US
dc.subjectmiRNAsen_US
dc.titleRole of miRNAs in diabetic neuropathy: mechanisms and possible interventionsen_US
dc.title.journalMolecular Neurobiologyen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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