Preparation of a Pt(II)-3-Hydroxy-2-tolyl-4H-chromen-4-one Complex Having Antimicrobial, Anticancerous, and Radical Scavenging Activities with Related Computational Studies

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dc.contributor.authorMohmad, Masrat
dc.contributor.authorAgnihotri, Nivedita
dc.contributor.authorKumar, Vikas
dc.contributor.authorAzam, Mohammad
dc.contributor.authorKamal, Raj
dc.contributor.authorKumar, Ashish
dc.contributor.authorSharma, Ujjawal
dc.contributor.authorJaved, Saleem
dc.contributor.authorMuthu, Sambantham
dc.contributor.authorMin, Kim
dc.date.accessioned2024-01-21T10:54:16Z
dc.date.accessioned2024-08-14T07:41:01Z
dc.date.available2024-01-21T10:54:16Z
dc.date.available2024-08-14T07:41:01Z
dc.date.issued2023-08-22T00:00:00
dc.description.abstractA novel benzopyran-based platinum (II)-3-hydroxy-2-tolyl-4H-chromen-4-one (HToC) complex has been prepared and studied by UV-visible spectrophotometry. The study is based on the colored complexation between Pt(II) and HToC in the pH range of 8.92-9.21, resulting in the formation of a stable binary yellow complex exhibiting ?max at 509-525 nm. The formed complex maintains linearity between 0.0 and 1.8 ?g Pt(II) mL-1. The well-known qualitative analytical methods, including Job�s method of continuous variations and the mole ratio approach, have both proven that the stoichiometry of the complex is 1:2 [Pt(II)/HToC]. Hence, the analytical results suggest that the formed platinum complex exhibits a square planar geometry. The values of various attributes corresponding to spectrophotometric studies and statistical calculations, such as the molar extinction coefficient (6.790 � 104 L mol-1 cm-1), Sandell�s sensitivity (0.0029 ?g Pt(II) cm-2), standard deviation (� 0.0011), RSD (0.317%), limit of detection (0.0147 ?g mL-1) and correlation coefficient (0.9999), show that the performed study satisfies all of the criteria for good sensitivity, versatility, and cost-effectiveness. In order to have an apprehension of the molecular geometry and other structural specifics of the complex, DFT studies have been carried out. The in vitro anticancer potential of the ligand and its platinum complex in the human breast cancer cell line (T-27D), as determined by the MTT assay, reveals that the complex has better antiproliferative potential than the ligand. The antimicrobial potential of the complex has been successfully tested against both Gram-positive and -negative bacteria. Antioxidant capacity results suggest the better radical scavenging capacity of the complex than that of the ligand. � 2023 The Authors. Published by American Chemical Societyen_US
dc.identifier.doi10.1021/acsomega.3c01316
dc.identifier.issn24701343
dc.identifier.urihttp://10.2.3.109/handle/32116/4265
dc.identifier.urlhttps://pubs.acs.org/doi/10.1021/acsomega.3c01316
dc.language.isoen_USen_US
dc.publisherAmerican Chemical Societyen_US
dc.titlePreparation of a Pt(II)-3-Hydroxy-2-tolyl-4H-chromen-4-one Complex Having Antimicrobial, Anticancerous, and Radical Scavenging Activities with Related Computational Studiesen_US
dc.title.journalACS Omegaen_US
dc.typeArticleen_US
dc.type.accesstypeOpen Accessen_US

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