Herbal Remedies for Improving Cancer Treatment Through Modulation of Redox Balance

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dc.contributor.authorKaur, Sukhchain
dc.contributor.authorVerma, Harkomal
dc.contributor.authorKaur, Sharanjot
dc.contributor.authorSingh, Subham
dc.contributor.authorMantha, Anil K.
dc.contributor.authorDhiman, Monisha
dc.date.accessioned2024-01-21T10:44:41Z
dc.date.accessioned2024-08-13T13:21:45Z
dc.date.available2024-01-21T10:44:41Z
dc.date.available2024-08-13T13:21:45Z
dc.date.issued2022-09-28T00:00:00
dc.description.abstractThe redox modulation induced by oxidative stress is one of the major cause of the metabolic and inflammatory disorders including cancer. The reactive oxygen species (ROS) produced by various sources in the cell shift the redox homeostasis of cells towards more oxidizing or acidic environment. This shift results in the alterations of normal physiologic functioning of biomolecules as well as causes damage to these biomolecules (proteins, lipids, and DNA/RNA). The excessive ROS and redox modulation are the key factors that support growth, progression, and survival of cancer cells. ROS-induced redox modulation further activates pro-tumorigenic cellular pathways for e.g., PI3K/AKT, HIF-1, and MAPK signaling pathways as well as hinders epigenetic signaling. Increasing evidences demonstrate that long-term side effects of anti-cancer chemotherapy are major concern of medical sciences although modern treatments are quite effective. The combination of various herbal formulations with anti-cancer therapy shows improvement in treatment effectiveness in cancer patients. Bioactive compounds present in herbal formulations possess antioxidant and anti-cancer properties that help in the regulation of redox status of cancer cells. The synergetic effects of herbal remedies along with conventional treatment are proven as novel therapeutics in cancer progression management. Clinical studies have shown that broad range of herbs and bioactive compounds from various plants having antioxidant, anti-inflammatory properties can suppress the carcinogenesis. In this chapter we will discuss the role of various plants such as Glycyrrhiza glabra, Picrorhiza kurroa, Tinospora cordifolia, Curcuma longa, Ocimum sanctum, Viola odorata, and bioactive compound ferulic acid found in various cereals. The chapter will also focus on various mechanisms involved in the modulation of chemo-toxicity and improvement of efficacy of conventional anti-cancer therapies by these plants. � Springer Nature Singapore Pte Ltd. 2022.en_US
dc.identifier.doi10.1007/978-981-16-5422-0_270
dc.identifier.isbn9789811654220
dc.identifier.isbn9789811654213
dc.identifier.urihttp://10.2.3.109/handle/32116/3831
dc.identifier.urlhttps://link.springer.com/10.1007/978-981-16-5422-0_270
dc.language.isoen_USen_US
dc.publisherSpringer Singaporeen_US
dc.subjectCanceren_US
dc.subjectHerbal formulationsen_US
dc.subjectOxidative stressen_US
dc.subjectRedox modulationen_US
dc.titleHerbal Remedies for Improving Cancer Treatment Through Modulation of Redox Balanceen_US
dc.title.journalHandbook of Oxidative Stress in Cancer: Therapeutic Aspects: Volume 1en_US
dc.typeBook chapteren_US
dc.type.accesstypeClosed Accessen_US

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