Bacillus calmette gaurine vaccine ameliorates the neurotoxicity of quinolinic acid in rats via the modulation of antioxidant, inflammatory and apoptotic markers

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dc.contributor.authorYedke, Narhari Gangaram
dc.contributor.authorArthur, Richmond
dc.contributor.authorKumar, Puneet
dc.date.accessioned2024-01-21T10:55:13Z
dc.date.accessioned2024-08-14T07:44:25Z
dc.date.available2024-01-21T10:55:13Z
dc.date.available2024-08-14T07:44:25Z
dc.date.issued2023-05-11T00:00:00
dc.description.abstractA mutation in the Huntingtin gene causes �Huntington's disease, which presents as a motor and behavioral impairment. Due to the limited drug therapy for this disease, scientists are constantly searching for newer and alternative drugs that may either retard or prevent the progress of the disease. This study aims to explore the neuroprotective potential of Bacillus Calmette Gaurine (BCG) vaccine against quinolinic acid-induced (QA) neurotoxicity in rats. QA (200 nmol/2 �l, i.s) was injected bilaterally into the rat striatum, after which a single dose of BCG (2 � 10^7, cfu) was given to the rats. Animals were assessed for behavioral parameters on the 14th and 21st days. On the 22nd day, animals were sacrificed, brains were harvested, and striatum was separated to evaluate biochemical, inflammatory, and apoptotic mediators. Histopathological studies were performed using Hematoxyline and Eosin staining to assess neuronal morphology. BCG treatment reversed motor abnormalities, reduced oxidative stress and neuroinflammatory markers, apoptotic mediators and striatal lesions induced by QA treatment. In conclusion, treat' 'ing rats with BCG vaccine (2 � 10^7, cfu) mitigated the quinolinic acid-induced Huntington's disease-like symptoms. Hence, BCG vaccine (2 �10^7, cfu) could be used as an adjuvant in managing HD. � 2023 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.jchemneu.2023.102287
dc.identifier.issn8910618
dc.identifier.urihttp://10.2.3.109/handle/32116/4373
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0891061823000571
dc.language.isoen_USen_US
dc.publisherElsevier B.V.en_US
dc.subjectHuntington's diseaseen_US
dc.subjectApoptosisen_US
dc.subjectBCG vaccineen_US
dc.subjectNeuroinflammationen_US
dc.subjectNeurotoxicityen_US
dc.subjectQuinolinic aciden_US
dc.titleBacillus calmette gaurine vaccine ameliorates the neurotoxicity of quinolinic acid in rats via the modulation of antioxidant, inflammatory and apoptotic markersen_US
dc.title.journalJournal of Chemical Neuroanatomyen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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