Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective

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dc.contributor.authorKumar, Adarsh
dc.contributor.authorSingh, Ankit Kumar
dc.contributor.authorSingh, Harshwardhan
dc.contributor.authorVijayan, Veena
dc.contributor.authorKumar, Deepak
dc.contributor.authorNaik, Jashwanth
dc.contributor.authorThareja, Suresh
dc.contributor.authorYadav, Jagat Pal
dc.contributor.authorPathak, Prateek
dc.contributor.authorGrishina, Maria
dc.contributor.authorVerma, Amita
dc.contributor.authorKhalilullah, Habibullah
dc.contributor.authorJaremko, Mariusz
dc.contributor.authorEmwas, Abdul-Hamid
dc.contributor.authorKumar, Pradeep
dc.date.accessioned2024-01-21T10:38:31Z
dc.date.accessioned2024-08-13T12:05:27Z
dc.date.available2024-01-21T10:38:31Z
dc.date.available2024-08-13T12:05:27Z
dc.date.issued2023-02-15T00:00:00
dc.description.abstractCancer is one of the major healthcare challenges across the globe. Several anticancer drugs are available on the market but they either lack specificity or have poor safety, severe side effects, and suffer from resistance. So, there is a dire need to develop safer and target-specific anticancer drugs. More than 85% of all physiologically active pharmaceuticals are heterocycles or contain at least one heteroatom. Nitrogen heterocycles constituting the most common heterocyclic framework. In this study, we have compiled the FDA approved heterocyclic drugs with nitrogen atoms and their pharmacological properties. Moreover, we have reported nitrogen containing heterocycles, including pyrimidine, quinolone, carbazole, pyridine, imidazole, benzimidazole, triazole, ?-lactam, indole, pyrazole, quinazoline, quinoxaline, isatin, pyrrolo-benzodiazepines, and pyrido[2,3-d]pyrimidines, which are used in the treatment of different types of cancer, concurrently covering the biochemical mechanisms of action and cellular targets. � 2023 by the authors.en_US
dc.identifier.doi10.3390/ph16020299
dc.identifier.issn14248247
dc.identifier.urihttp://10.2.3.109/handle/32116/3592
dc.identifier.urlhttps://www.mdpi.com/1424-8247/16/2/299
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.subjectanti-canceren_US
dc.subjectbiological activityen_US
dc.subjectFDAen_US
dc.subjectheterocyclicen_US
dc.subjectnitrogen-containing heterocyclicen_US
dc.titleNitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspectiveen_US
dc.title.journalPharmaceuticalsen_US
dc.typeReviewen_US
dc.type.accesstypeOpen Accessen_US

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Pharmaceutical Sciences and Natural Products - Research Publications