Isolation, Characterization, and Quantification of a New Anticancer Constituent from Leaves of Nyctanthes arbor-tristis

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dc.contributor.authorGrover, P.
dc.contributor.authorKaur, J.
dc.contributor.authorSuri, K.A.
dc.contributor.authorKumar, R.
dc.contributor.authorBansal, G.
dc.date.accessioned2024-01-21T10:38:21Z
dc.date.accessioned2024-08-13T12:05:16Z
dc.date.available2024-01-21T10:38:21Z
dc.date.available2024-08-13T12:05:16Z
dc.date.issued2022-05-03T00:00:00
dc.description.abstractA new compound, 1,1,2-tris(2?,4?-di-tert-butylphenyl)-4,4-dimethylpent-1-ene, was isolated and characterized from the leaves of Nyctanthes arbor-tristis L. The plant was subjected to bioactivity-guided fractionation, and a compound was isolated from chloroform extract that was found to have potent anticancer activity. The chloroform extract was further fractionated, and a pure compound was isolated that was found to be active against three cancer cell lines (HL-60, HCT-116, and A-549). An RP-HPLC method was developed for quantification of the isolated compound. The content of the isolated compound was 0.88% in the chloroform extract and 0.08% in N. arbor-tristis leaves. � 2022, Springer Science+Business Media, LLC, part of Springer Nature.en_US
dc.identifier.doi10.1007/s10600-022-03639-4
dc.identifier.issn93130
dc.identifier.urihttps://kr.cup.edu.in/handle/32116/3543
dc.identifier.urlhttps://link.springer.com/10.1007/s10600-022-03639-4
dc.language.isoen_USen_US
dc.publisherSpringeren_US
dc.subjectanticanceren_US
dc.subjectextractionen_US
dc.subjectfractionationen_US
dc.subjectHPLCen_US
dc.subjectisolationen_US
dc.subjectNyctanthes arbor-tristisen_US
dc.subjectspectroscopyen_US
dc.titleIsolation, Characterization, and Quantification of a New Anticancer Constituent from Leaves of Nyctanthes arbor-tristisen_US
dc.title.journalChemistry of Natural Compoundsen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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