Association of APOE (E2, E3 and E4) gene variants and lipid levels in ischemic stroke, its subtypes and hemorrhagic stroke in a South Indian population

dc.contributor.authorDas, Satrupa
dc.contributor.authorKaul, Subhash
dc.contributor.authorJyothy, Akka
dc.contributor.authorMunshi, Anjana
dc.date.accessioned2018-07-14T01:18:34Z
dc.date.accessioned2024-08-14T07:41:07Z
dc.date.available2018-07-14T01:18:34Z
dc.date.available2024-08-14T07:41:07Z
dc.date.issued2016
dc.description.abstractIn the present study we evaluated the association of APOE (E2/E3/E4) polymorphism with ischemic stroke (n = 620), its subtypes and hemorrhagic stroke (n = 250) in a South Indian population from Telangana. The genotypes were determined using PCR-RFLP while lipid levels were measured using commercially available kits. We found significant difference in the genotypic distribution between hemorrhagic stroke patients and controls for certain genetic models [E2/E2 vs. E2/E4; E3/E3 vs. E2/E3; E3/E3 vs. E2/E4; E4/E4 vs. E2/E3; E4/E4 vs.E2/E4 and E3 vs. E4]. However, no significant difference was observed in genotypic distribution between ischemic stroke patients and controls. On analysing the genotypic distribution between ischemic and hemorrhagic stroke patients, statistically significant difference was observed in specific genetic models [E2/E2 vs. E2/E4; E3/E3 vs. E2/E3; E3/E3 vs. E2/E4; E4/E4 vs. E2/E3 and E4/E4 vs. E2/E4]. In ischemic stroke subtypes analysing for alleles E3 vs. E2 and E3 vs. E4, we found significant association with intracranial large artery (p = 0.01), cardioembolic stroke (p = 0.001 and p = 0.0004) and lacunar stroke (p = 0.02). Analysing the association of various genotypes with different lipid levels significant association was observed for VLDL (P = 0.000) and for triglyceride (P = 0.000) levels with E2/E4 and E3/E4 genotypes in ischemic stroke but not in hemorrhagic stroke. In conclusion, our results suggest that APOE polymorphism does seem to play a role in hemorrhagic stroke and also in the development of specific subtypes of ischemic stroke. Further, in ischemic stroke VLDL and triglycerides levels were found to be significantly associated with E2/E4 and E3/E4 genotypes. ? 2016 Elsevier Ireland Ltd.en_US
dc.identifier.citationDas, S., Kaul, S., Jyothy, A., & Munshi, A. (2016). Association of APOE (E2, E3 and E4) gene variants and lipid levels in ischemic stroke, its subtypes and hemorrhagic stroke in a South Indian population. Neuroscience Letters, 628, 136-141. doi: 10.1016/j.neulet.2016.06.032en_US
dc.identifier.doi10.1016/j.neulet.2016.06.032
dc.identifier.issn3043940
dc.identifier.urihttps://kr.cup.edu.in/handle/32116/1240
dc.identifier.urlhttps://www.sciencedirect.com/science/article/abs/pii/S0304394016304414
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.subjectApolipoprotein E2en_US
dc.subjectApolipoprotein E3en_US
dc.subjectApolipoprotein E4en_US
dc.subjectLipiden_US
dc.subjectTriacylglycerolen_US
dc.subjectVery Low Density Lipoproteinen_US
dc.subjectApoe Protein, Humanen_US
dc.subjectApolipoprotein Een_US
dc.subjectApolipoprotein E2en_US
dc.subjectApolipoprotein E3en_US
dc.subjectApolipoprotein E4en_US
dc.subjectHigh Density Lipoprotein Cholesterolen_US
dc.subjectLow Density Lipoprotein Cholesterolen_US
dc.subjectTriacylglycerolen_US
dc.subjectVery Low Density Lipoprotein Cholesterolen_US
dc.subjectAdult Brain Hemorrhageen_US
dc.subjectBrain Ischemiaen_US
dc.subjectCardioembolic Strokeen_US
dc.subjectControlled Studyen_US
dc.subjectFemaleen_US
dc.subjectGenetic Associationen_US
dc.subjectGenetic Variationen_US
dc.subjectGenotypeen_US
dc.subjectHumanen_US
dc.subjectIndien_US
dc.titleAssociation of APOE (E2, E3 and E4) gene variants and lipid levels in ischemic stroke, its subtypes and hemorrhagic stroke in a South Indian populationen_US
dc.title.journalNeuroscience Letters
dc.typeArticleen_US

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