Zebrafish as an emerging tool for drug discovery and development for thyroid diseases

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dc.contributor.authorYadav, Poonam
dc.contributor.authorSarode, Lopmudra P.
dc.contributor.authorGaddam, Ravinder Reddy
dc.contributor.authorKumar, Puneet
dc.contributor.authorBhatti, Jasvinder Singh
dc.contributor.authorKhurana, Amit
dc.contributor.authorNavik, Umashanker
dc.date.accessioned2024-01-21T10:55:05Z
dc.date.accessioned2024-08-14T07:44:21Z
dc.date.available2024-01-21T10:55:05Z
dc.date.available2024-08-14T07:44:21Z
dc.date.issued2022-09-06T00:00:00
dc.description.abstractZebrafish is a useful model for understanding human genetics and diseases and has evolved into a prominent scientific research model. The genetic structure of zebrafish is 70% identical to that of humans. Its small size, low cost, and transparent embryo make it a valuable tool in experimentation. Zebrafish and mammals possess the same molecular mechanism of thyroid organogenesis and development. Thus, thyroid hormone signaling, embryonic development, thyroid-related disorders, and novel genes involved in early thyroid development can all be studied using zebrafish as a model. Here in this review, we emphasize the evolving role of zebrafish as a possible tool for studying the thyroid gland in the context of physiology and pathology. The transcription factors nkx2.1a, pax2a, and hhex which contribute a pivotal role in the differentiation of thyroid primordium are discussed. Further, we have described the role of zebrafish as a model for thyroid cancer, evaluation of defects in thyroid hormone transport, thyroid hormone (TH) metabolism, and as a screening tool to study thyrotoxins. Hence, the present review highlights the role of zebrafish as a novel approach to understand thyroid development and organogenesis. � 2022 Elsevier Ltden_US
dc.identifier.doi10.1016/j.fsi.2022.09.001
dc.identifier.issn10504648
dc.identifier.urihttp://10.2.3.109/handle/32116/4335
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S1050464822005514
dc.language.isoen_USen_US
dc.publisherAcademic Pressen_US
dc.subjectDisease modelen_US
dc.subjectTherapeutic toolen_US
dc.subjectThyroid disordersen_US
dc.subjectThyroid glanden_US
dc.subjectZebrafishen_US
dc.titleZebrafish as an emerging tool for drug discovery and development for thyroid diseasesen_US
dc.title.journalFish and Shellfish Immunologyen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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