A Pleiotropic Role of Long Non-Coding RNAs in the Modulation of Wnt/?-Catenin and PI3K/Akt/mTOR Signaling Pathways in Esophageal Squamous Cell Carcinoma: Implication in Chemotherapeutic Drug Response

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dc.contributor.authorSharma, Uttam
dc.contributor.authorMurmu, Masang
dc.contributor.authorBarwal, Tushar Singh
dc.contributor.authorTuli, Hardeep Singh
dc.contributor.authorJain, Manju
dc.contributor.authorPrakash, Hridayesh
dc.contributor.authorKaceli, Tea
dc.contributor.authorJain, Aklank
dc.contributor.authorBishayee, Anupam
dc.date.accessioned2024-01-16T14:23:12Z
dc.date.accessioned2024-08-13T10:34:09Z
dc.date.available2024-01-16T14:23:12Z
dc.date.available2024-08-13T10:34:09Z
dc.date.issued2022-03-28T00:00:00
dc.description.abstractDespite the availability of modern techniques for the treatment of esophageal squamous cell carcinoma (ESCC), tumor recurrence and metastasis are significant challenges in clinical management. Thus, ESCC possesses a poor prognosis and low five-year overall survival rate. Notably, the origin and recurrence of the cancer phenotype are under the control of complex cancer-related signaling pathways. In this review, we provide comprehensive knowledge about long non-coding RNAs (lncRNAs) related to Wnt/?-catenin and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway in ESCC and its implications in hindering the efficacy of chemotherapeutic drugs. We observed that a pool of lncRNAs, such as HERES, TUG1, and UCA1, associated with ESCC, directly or indirectly targets various molecules of the Wnt/?-catenin pathway and facilitates the manifestation of multiple cancer phenotypes, including proliferation, metastasis, relapse, and resistance to anticancer treatment. Additionally, several lncRNAs, such as HCP5 and PTCSC1, modulate PI3K/Akt/mTOR pathways during the ESCC pathogenesis. Furthermore, a few lncRNAs, such as AFAP1-AS1 and LINC01014, block the efficiency of chemotherapeutic drugs, including cisplatin, 5-fluorouracil, paclitaxel, and gefitinib, used for ESCC treatment. Therefore, this review may help in designing a better therapeutic strategy for ESCC patients. � 2022 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.identifier.doi10.3390/curroncol29040189
dc.identifier.issn17187729
dc.identifier.urihttps://doi.org/10.3390/curroncol29040189
dc.identifier.urihttp://10.2.3.109/handle/32116/2871
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.subjectchemotherapyen_US
dc.subjectesophageal squamous cell carcinomaen_US
dc.subjectlong non-coding RNAsen_US
dc.subjectPI3K/Akt/mTORen_US
dc.subjectsignaling pathwaysen_US
dc.subjectWnt/?-cateninen_US
dc.titleA Pleiotropic Role of Long Non-Coding RNAs in the Modulation of Wnt/?-Catenin and PI3K/Akt/mTOR Signaling Pathways in Esophageal Squamous Cell Carcinoma: Implication in Chemotherapeutic Drug Responseen_US
dc.title.journalCurrent Oncologyen_US
dc.typeReviewen_US
dc.type.accesstypeOpen Accessen_US

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