Neuroprotective effect of silymarin against 3-Nitropropionic acid-induced neurotoxicity in rats

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dc.contributor.authorChandolia, Priyanka
dc.contributor.authorRahi, Vikrant
dc.contributor.authorKumar, Puneet
dc.date.accessioned2024-01-21T10:55:06Z
dc.date.accessioned2024-08-14T07:44:21Z
dc.date.available2024-01-21T10:55:06Z
dc.date.available2024-08-14T07:44:21Z
dc.date.issued2022-09-20T00:00:00
dc.description.abstract(HD) Huntington's disease is a severe hereditary catastrophic neurological disease with an autosomal dominant heritable changes manifested by cognitive, behavioural, and motor progression deficits, resulting in death. Several mechanisms are involved in the pathogenesis of this complex and rare disease, including excitotoxicity, mitochondrial dysfunction, neurotransmitters imbalance, and oxidative stress. Silymarin was selected as an investigational drug, due to its numerous activities in current research, it possesses substantial antioxidant and neuroprotective functionalities. The present research attempts, i.p. injections of 3-NPA (10 ?mg/kg) were given for 21 days to trigger Huntington-like symptoms in rats. The percentage fluctuations in body weight, the footfall counts, and the time required to transverse the beam and motor functions were analyzed at multiple time points. Oxidative stress markers like MDA/LPO, GSH, protein, nitrite, catalase, and superoxide dismutase levels were examined in the striatum region. The current study results conclusively demonstrate that chronic 3-NPA administration significantly decreased the body weight and showed marked abnormalities in motor coordination, locomotion, and increased striatal generation of free radicals. Furthermore, treatment with silymarin (100 & 200 ?mg/kg/p.o.), mitigated 3-NPA triggered behavioural and biochemical alterations. Our study results could conclude that Silymarin may be advantageous and might develop an adjuvant treatment for the management of Huntington's disease. � 2022 The Authorsen_US
dc.identifier.doi10.1016/j.crphar.2022.100130
dc.identifier.issn25902571
dc.identifier.urihttp://10.2.3.109/handle/32116/4336
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S2590257122000505
dc.language.isoen_USen_US
dc.publisherElsevier B.V.en_US
dc.subject3-NPA- 3-Nitropropionic aciden_US
dc.subjectGlutamateen_US
dc.subjectHD- Huntington's diseaseen_US
dc.subjectMitochondrial dysfunctionen_US
dc.subjectOxidative stress markersen_US
dc.subjectSilymarinen_US
dc.titleNeuroprotective effect of silymarin against 3-Nitropropionic acid-induced neurotoxicity in ratsen_US
dc.title.journalCurrent Research in Pharmacology and Drug Discoveryen_US
dc.typeArticleen_US
dc.type.accesstypeOpen Accessen_US

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