Role of Omics in Migraine Research and Management: A Narrative Review

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dc.contributor.authorChaturvedi, Pragya
dc.contributor.authorKhan, Rahul
dc.contributor.authorSahu, Prachi
dc.contributor.authorLudhiadch, Abhilash
dc.contributor.authorSingh, Gagandeep
dc.contributor.authorMunshi, Anjana
dc.date.accessioned2024-01-21T10:54:07Z
dc.date.accessioned2024-08-14T07:40:52Z
dc.date.available2024-01-21T10:54:07Z
dc.date.available2024-08-14T07:40:52Z
dc.date.issued2022-07-07T00:00:00
dc.description.abstractMigraine is a neurological disorder defined by episodic attacks of chronic pain associated with nausea, photophobia, and phonophobia. It is known to be a complex disease with several environmental and genetic factors contributing to its susceptibility. Risk factors for migraine include head or neck injury (Arnold, Cephalalgia 38(1):1�211, 2018). Stress and high temperature are known to trigger migraine, while sleep disorders and anxiety are considered to be the comorbid conditions with migraine. Studies have reported various biomarkers, including genetic variants, proteins, and metabolites implicated in migraine�s pathophysiology. Using the �omics� approach, which deals with genetics, transcriptomics, proteomics, and metabolomics, more specific biomarkers for various migraine can be identified. On account of its multifactorial nature, migraine is an ideal study model focusing on integrated omics approaches, including genomics, transcriptomics, proteomics, and metabolomics. The current review has been compiled with an aim to focus on the genomic alterations especially involved in the regulation of glutamatergic neurotransmission, cortical excitability, ion channels, solute carrier proteins, or receptors; their expression in migraine patients and also specific proteins and metabolites, including some inflammatory biomarkers that might represent the migraine phenotype at the molecular level. The systems biology approach holds the promise to understand the pathophysiology of the disease at length and also to identify the specific therapeutic targets for novel interventions. � 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.en_US
dc.identifier.doi10.1007/s12035-022-02930-3
dc.identifier.issn8937648
dc.identifier.urihttp://10.2.3.109/handle/32116/4218
dc.identifier.urlhttps://link.springer.com/10.1007/s12035-022-02930-3
dc.language.isoen_USen_US
dc.publisherSpringeren_US
dc.subjectGABAen_US
dc.subjectIon channelsen_US
dc.subjectMigraineen_US
dc.subjectNeurotransmissionen_US
dc.titleRole of Omics in Migraine Research and Management: A Narrative Reviewen_US
dc.title.journalMolecular Neurobiologyen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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