Zingiber roseum Roscoe. (Zingiberaceae): Current and future perspective

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dc.contributor.authorAmanat, Muhammed
dc.contributor.authorGautam, Swati
dc.contributor.authorChalotra, Rishabh
dc.contributor.authorLal, Kanhaiya
dc.contributor.authorGupta, Tanya
dc.contributor.authorAgrawal, Rohini
dc.contributor.authorMojwar, Somdutt
dc.contributor.authorSingh, Randhir
dc.date.accessioned2024-01-21T10:55:13Z
dc.date.accessioned2024-08-14T07:44:25Z
dc.date.available2024-01-21T10:55:13Z
dc.date.available2024-08-14T07:44:25Z
dc.date.issued2023-05-07T00:00:00
dc.description.abstractIntroduction: A perennial, aromatic, tuberose plant Zingiber roseum (Roscoe.) (Zingiberaceae), flourishes in tropical and subtropical climates. In Traditional Chinese Medicine, several pharmacological properties of Zingiber roseum have been reported its antiseptic, antivertigo, and antidiarrheal activities. Therefore, the present article aims to provide insights into the ethnomedicinal, phytochemistry, and pharmacology of Zingiber roseum. Methods: The literature was compelled after systematically searching scientific databases, including Scopus, PubMed, Google Scholar, and Research Gate. The selection criteria for the plant comprised the therapeutic potential of Zingiber roseum and its active components. Moreover, to explore anti-diabetic activity, ligands of interest from Z. roseum were evaluated for their affinity towards PPAR-? and PPAR-?. Results and discussions: Out of 200 articles, 140 were selected for the current study, and from the para-topic literature, it was found that Zingiber roseum has numerous pharmacological properties due to the presence of phytoconstituents like flavonoids, alkaloids, phenolic chemicals, terpenoids, saponins, and phytosterols. Furthermore, in silico studies were carried out using PyRx. It was found that rosmarinic acid (-8.3 kcal/mol) and stigmasterol (-11.12 kcal/mol) exhibited the highest binding affinities for PPAR-? and PPAR-?, respectively, when compared to standard Rosiglitazone. Conclusion: It may be concluded that Z. roseum has several therapeutic activities. Moreover, in silico studies revealed the anti-diabetic action of Z. roseum via modulation of PPAR-? and PPAR-?. � 2023 The Author(s)en_US
dc.identifier.doi10.1016/j.prmcm.2023.100258
dc.identifier.issn26671425
dc.identifier.urihttp://10.2.3.109/handle/32116/4372
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S2667142523000441
dc.language.isoen_USen_US
dc.publisherElsevier B.V.en_US
dc.subjectPAR-?en_US
dc.subjectPAR-?en_US
dc.subjectRosmarinic aciden_US
dc.subjectSitgmasterolen_US
dc.subjectZingiber roseumen_US
dc.subjectZingiberaceaeen_US
dc.titleZingiber roseum Roscoe. (Zingiberaceae): Current and future perspectiveen_US
dc.title.journalPharmacological Research - Modern Chinese Medicineen_US
dc.typeReviewen_US
dc.type.accesstypeOpen Accessen_US

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