Caulerpa taxifolia inhibits cell proliferation and induces oxidative stress in breast cancer cells

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dc.contributor.authorMehra, Richa
dc.contributor.authorBhushan, Satej
dc.contributor.authorYadav, Umesh Prasad
dc.contributor.authorBast, Felix
dc.contributor.authorSingh, Sandeep
dc.date.accessioned2019-03-26T09:04:59Z
dc.date.accessioned2024-08-13T11:02:32Z
dc.date.available2019-03-26T09:04:59Z
dc.date.available2024-08-13T11:02:32Z
dc.date.issued2018
dc.description.abstractCaulerpa taxifolia (M. Vahl) C. Agardh or killer alga is known to possess several bioactive secondary metabolites with unique structural modifications. We investigated anti-oxidant and anti-proliferative activity of C. taxifolia extract (CTE) on breast and lung cancer cells, along with possible effects on mitochondrial membrane potential (MMP) and cell cycle progression. The results revealed up to 6-folds increase in reactive oxygen species (ROS), 2-folds increase in glutathione reductase (GR) activity, 1.7-fold increase in superoxide dismutase (SOD) activity and 1.8-fold change in catalase activity w.r.t. untreated cells i.e. 10.72 to 21.44 nmol/min/mL, 2.0 to 3.49 U/mL and 37.51 to 69.26 U/min/g FW, respectively, in MDA-MB-cells. Likewise, selective anti-proliferative activity with IC50 0.19 + 0.1, 0.27 + 0.1, and 0.43 + 0.1 μg/μL, was recorded in MDA-MB-231, T-47D, and H1299 cells. In addition, dose-dependent increase in MMP of up to 40% and G1/S phase mitotic arrest was documented by CTE treatment in MDA-MB-231 cells. The results suggest an anti-proliferative and oxidative stress inducing activity of CTE. Changes in MMP and cell cycle arrest further support the anti-cancer effects of CTE. It is believed that C. taxifolia may be considered as a potent source of anti-cancer drugs, subject to further validations.en_US
dc.identifier.citationMehra, R., Bhushan, S., Yadav, U.P. et al. (2018) Caulerpa taxifolia inhibits cell proliferation and induces oxidative stress in breast cancer cells. Biologia . 74: 187. https://doi.org/10.2478/s11756-018-0163-xen_US
dc.identifier.doi10.2478/s11756-018-0163-x
dc.identifier.issnPrint-0006-3088
dc.identifier.issnOnline-1336-9563
dc.identifier.urihttp://10.2.3.109/handle/32116/2212
dc.identifier.urlhttps://link.springer.com/article/10.2478%2Fs11756-018-0163-x
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectCaulerpa taxifoliaen_US
dc.subjectMarine algaen_US
dc.subjectKiller algaen_US
dc.subjectCanceren_US
dc.subjectOxidative stressen_US
dc.titleCaulerpa taxifolia inhibits cell proliferation and induces oxidative stress in breast cancer cellsen_US
dc.title.journalBiolgiaen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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