Animal models of Huntington�s disease and their applicability to novel drug discovery and development

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dc.contributor.authorUpadhayay, Shubham
dc.contributor.authorJamwal, Sumit
dc.contributor.authorKumar, Puneet
dc.date.accessioned2024-01-21T10:55:12Z
dc.date.accessioned2024-08-14T07:44:25Z
dc.date.available2024-01-21T10:55:12Z
dc.date.available2024-08-14T07:44:25Z
dc.date.issued2023-04-12T00:00:00
dc.description.abstractIntroduction: Huntington�s disease (HD) is a progressive neurodegenerative disorder caused by an expansion in the CAG trinucleotide repeat in huntingtin (Htt) gene. The discovery of the HD-causing gene prompted the creation of new HD animal models, proving that mutations in the HD gene are linked to either loss of function of the wild-type (un-mutated) gene or toxic gain in the function of a mutated gene. Areas Covered: Animal models of HD have led to an increased understanding of its pathogenesis and resulted in the discovery of new therapeutic targets/drugs. The focus of this review is on the selection and validation of animal models for HD drug discovery. Furthermore, several drugs tested using various models in the preclinical phase have been compiled to demonstrate the applicability of these HD animal models. Expert opinion: The applicability of animal models for HD drug discovery has been well demonstrated. Nevertheless, despite the enormous progression made to date, the development of drug therapy to completely alleviate disease progression has not been achieved. Most of the pre-clinically tested drugs have shown promising results in alleviating HD-associated neurodegeneration and motor and non-motor symptoms, but only a few of them thrived to produce satisfactory results in the clinical phase. This failure has raised concerns about the selection of HD animal models and species, and new strategies for selection are mandated. � 2023 Informa UK Limited, trading as Taylor & Francis Group.en_US
dc.identifier.doi10.1080/17460441.2023.2201493
dc.identifier.issn17460441
dc.identifier.urihttp://10.2.3.109/handle/32116/4369
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.1080/17460441.2023.2201493
dc.language.isoen_USen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.subjectanimal modelsen_US
dc.subjectdrug developmenten_US
dc.subjectdrug discoveryen_US
dc.subjectHuntington�s diseaseen_US
dc.subjectneurodegenerationen_US
dc.titleAnimal models of Huntington�s disease and their applicability to novel drug discovery and developmenten_US
dc.title.journalExpert Opinion on Drug Discoveryen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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