Increased incidence of spontaneous abortions on exposure to cadmium and lead: a systematic review and meta-analysis

dc.contributor.authorKaur, Mandeep
dc.contributor.authorSharma, Priya
dc.contributor.authorKaur, Rajinder
dc.contributor.authorKhetarpal, Preeti
dc.date.accessioned2024-01-21T10:54:01Z
dc.date.accessioned2024-08-14T07:40:47Z
dc.date.available2024-01-21T10:54:01Z
dc.date.available2024-08-14T07:40:47Z
dc.date.issued2021-06-25T00:00:00
dc.description.abstractBackground: Spontaneous abortions are the most severe complication of early pregnancy and are a major reproductive health problem. Although this could be caused due to various cytogenetic, immunological, or endocrinological reasons, role of environmental toxicants cannot be ruled out. In order to explore the role of cadmium and lead in causing spontaneous abortions, current systematic review and meta-analysis had been carried out. Methodology: Literature search was performed using appropriate keywords in PubMed, Science Direct, Cochrane Library, and Google Scholar databases up to December 25 2020 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA). Metananalysis was carried out with the help of RevMan software (version 5.3). Results: Meta-analysis of nine studies on cadmium concentrations in blood of women with at least one spontaneous abortions and controls revealed standardized mean difference (SMD)=3.39, 95% CI (2.17, 4.61), with p <.05. Similarly, meta-analysis of eight studies on lead concentrations revealed standardized mean difference (SMD)=6.24, 95% CI (4.34, 8.14), with p <.05. Conclusion: Populations exposed to heavy metals such as cadmium and lead are at higher risk of pregnancy loss. Therefore, couples experiencing repeated pregnancy losses may be screened for heavy metal load. � 2021 Informa UK Limited, trading as Taylor & Francis Group.en_US
dc.identifier.doi10.1080/09513590.2021.1942450
dc.identifier.issn9513590
dc.identifier.urihttps://kr.cup.edu.in/handle/32116/4185
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.1080/09513590.2021.1942450
dc.language.isoen_USen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.subjectCadmium (Cd)en_US
dc.subjectlead (Pb)en_US
dc.subjectmeta-analysisen_US
dc.subjectspontaneous abortionsen_US
dc.subjectsystematic reviewen_US
dc.subjecttoxicityen_US
dc.titleIncreased incidence of spontaneous abortions on exposure to cadmium and lead: a systematic review and meta-analysisen_US
dc.title.journalGynecological Endocrinologyen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

Files