Natural Compound-Based Nanoparticles to Target Free Radicals in Cancer

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dc.contributor.authorYadav, Umesh Prasad
dc.contributor.authorRhuthuparna, M.
dc.contributor.authorVasudeva, Kanika
dc.contributor.authorSuman, Prabhat
dc.contributor.authorMunshi, Anjana
dc.contributor.authorKumar, Santosh
dc.contributor.authorSingh, Sandeep
dc.date.accessioned2024-01-21T10:54:08Z
dc.date.accessioned2024-08-14T07:40:53Z
dc.date.available2024-01-21T10:54:08Z
dc.date.available2024-08-14T07:40:53Z
dc.date.issued2022-09-28T00:00:00
dc.description.abstractCell proliferation and malignant transformation are enabled by genetic and epigenetic changes. During the malignancy process, malignant cells acquire distinguishing characteristics. Cancer cells have acquired the ability to generate more reactive oxygen species (ROS), resulting in high oxidative stress. ROS-mediated signaling is needed for cancer cell physiology, and high levels of ROS cause oxidative stress-induced cytotoxicity in cancer cells. To avoid ROS-mediated cytotoxicity, cancer cells modulate their redox state through various antioxidant mechanisms and keep their ROS levels below the threshold. Cancer treatment that targets oxidative stress is an appealing option. Many natural oxidative stress modulators and bioactive compounds have been used in the treatment of cancer. Conventional uptake of bioactive molecule is associated with lower bioavailability, solubility, unlikely biodistribution, and side effects. Traditional drug uptake is improved by nanoformulation, making it easier to overcome side effects, improve biodistribution, and extend drug duration time. Natural prooxidant-loaded nanoparticles efficiently carry prooxidant to the tumor site and selectively and efficiently induce oxidative stress-mediated cell death in cancer cells. � Springer Nature Singapore Pte Ltd. 2022.en_US
dc.identifier.doi10.1007/978-981-16-5422-0_276
dc.identifier.isbn9789811654220
dc.identifier.isbn9789811654213
dc.identifier.urihttp://10.2.3.109/handle/32116/4226
dc.identifier.urlhttps://link.springer.com/10.1007/978-981-16-5422-0_276
dc.language.isoen_USen_US
dc.publisherSpringer Singaporeen_US
dc.subjectNanoparticleen_US
dc.subjectOxidative stressen_US
dc.subjectProoxidanten_US
dc.subjectReactive oxygen species and canceren_US
dc.titleNatural Compound-Based Nanoparticles to Target Free Radicals in Canceren_US
dc.title.journalHandbook of Oxidative Stress in Cancer: Therapeutic Aspects: Volume 1en_US
dc.typeBook chapteren_US
dc.type.accesstypeClosed Accessen_US

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Human Genetics And Molecular Medicine - Research Publications