Biosynthesis of Zinc Oxide Nanoparticles Using Catharanthus Roseus Leaves and Their Therapeutic Response in Breast Cancer (MDA-MB-231) Cells

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dc.contributor.authorBangroo, Apoorva
dc.contributor.authorMalhotra, Akshay
dc.contributor.authorSharma, Uttam
dc.contributor.authorJain, Aklank
dc.contributor.authorKaur, Anupreet
dc.date.accessioned2024-01-21T10:44:36Z
dc.date.accessioned2024-08-13T13:22:22Z
dc.date.available2024-01-21T10:44:36Z
dc.date.available2024-08-13T13:22:22Z
dc.date.issued2021-07-26T00:00:00
dc.description.abstractAs the current study reports the utilization of the leaf extract of Catharanthus roseus (C.roseus) for the biological synthesis of zinc oxide nanoparticles (ZnO NPs) because of the importance of the importance of health and environment. Bioinspired synthesis were characterized using Fourier Transform Infrared Spectroscopy (FT-IR), Field Emission-Scanning Electron Microscopy (FE-SEM), Transmission Electron Microscopy (TEM), Energy-Dispersive X-ray Spectroscopy (EDX) and X-Ray diffraction (XRD). XRD and TEM micrograph analysis revealed that the synthesized nanostructures were well-dispersed and spherical with the average particle size in the 18-30 nm range were produced. The FT-IR spectra confirmed presence of phenolic compounds that act as reducing and capping agents. Further, it suggested the possible utilization of hydroxyl groups and amides in the reduction of Zn ions and stablization of ZnO NPs. Zinc oxide nanomaterials are effective in cancer treatments, including the destruction of tumor cells with minimal damage to healthy cells. The toxicity of zinc oxide nanomaterials was checked in vitro in the human breast cancer line MDA-MB-231. Inverse relation of the percentage of viable cells to the concentration of zinc oxide nanomaterials at increasing molar levels was assessed. The cytotoxicity analysis used in the MTT test shows the substantial viable MDA-MB-231-cells despite the increased concentration of exposure to zinc oxide nanomaterials. Reduction in the ratio of viable MDA-MB-231 cells after being exposed to zinc oxide nanomaterials was compared to untreated cancerous cells. The present approach to biosynthesis is quick, inexpensive, eco-friendly, and high-rise stable nanomaterials of zinc oxide with substantial cancer potential. This is the first study that reports molar concentrations (with the lowest concentration of 10 mM) as an anticancer agent for breast cancer and potential clinical uses for synthesized zinc oxide nanomaterials. Thus, C. roseus based synthesized ZnO NPs could be explored not only as environmentally benign method but also as a potential anti-carcinogenic agent. � 2022 Taylor & Francis Group, LLC.en_US
dc.identifier.doi10.1080/01635581.2021.1952622
dc.identifier.issn1635581
dc.identifier.urihttp://10.2.3.109/handle/32116/3804
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.1080/01635581.2021.1952622
dc.language.isoen_USen_US
dc.publisherRoutledgeen_US
dc.subjectAnti-Bacterial Agentsen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectCatharanthusen_US
dc.subjectFemaleen_US
dc.subjectGreen Chemistry Technologyen_US
dc.subjectHumansen_US
dc.subjectMetal Nanoparticlesen_US
dc.subjectMicrobial Sensitivity Testsen_US
dc.subjectNanoparticlesen_US
dc.subjectPlant Extractsen_US
dc.subjectPlant Leavesen_US
dc.subjectSpectroscopy, Fourier Transform Infrareden_US
dc.subjectZinc Oxideen_US
dc.subjectamideen_US
dc.subjectantineoplastic agenten_US
dc.subjectCatharanthus roseus extracten_US
dc.subjecthydroxyl groupen_US
dc.subjectnanomaterialen_US
dc.subjectphenol derivativeen_US
dc.subjectzinc oxide nanoparticleen_US
dc.subjectantiinfective agenten_US
dc.subjectmetal nanoparticleen_US
dc.subjectnanoparticleen_US
dc.subjectplant extracten_US
dc.subjectzinc oxideen_US
dc.subjectArticleen_US
dc.subjectbiosynthesisen_US
dc.subjectbreast canceren_US
dc.subjectCatharanthus roseusen_US
dc.subjectcell viabilityen_US
dc.subjectconcentration (parameter)en_US
dc.subjectcontrolled studyen_US
dc.subjectcytotoxicityen_US
dc.subjectenergy dispersive X ray spectroscopyen_US
dc.subjectfield emission scanning electron microscopyen_US
dc.subjectFourier transform infrared spectroscopyen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectIndiaen_US
dc.subjectMDA-MB-231 cell lineen_US
dc.subjectMTT assayen_US
dc.subjectnanotechnologyen_US
dc.subjectnonhumanen_US
dc.subjectplant leafen_US
dc.subjecttraditional medicineen_US
dc.subjecttransmission electron microscopyen_US
dc.subjecttreatment responseen_US
dc.subjectX ray diffractionen_US
dc.subjectbreast tumoren_US
dc.subjectCatharanthusen_US
dc.subjectchemistryen_US
dc.subjectfemaleen_US
dc.subjectgreen chemistryen_US
dc.subjectinfrared spectroscopyen_US
dc.subjectmicrobial sensitivity testen_US
dc.subjectproceduresen_US
dc.titleBiosynthesis of Zinc Oxide Nanoparticles Using Catharanthus Roseus Leaves and Their Therapeutic Response in Breast Cancer (MDA-MB-231) Cellsen_US
dc.title.journalNutrition and Canceren_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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