Antiproliferative Activity of Chloroform and Methanol Extracts of Piper attenuatum (Buch-Ham)

Simple item page
dc.contributor.authorPathak, Neha
dc.contributor.supervisorKumar, Raj
dc.date.accessioned2018-08-31T04:13:49Z
dc.date.accessioned2024-08-13T11:24:40Z
dc.date.available2018-08-31T04:13:49Z
dc.date.available2024-08-13T11:24:40Z
dc.date.issued2018
dc.description.abstractIndian traditional medicinal plant Piper attenuatum (Buch-Ham) has been investigated for its antiproliferative activity. Dried powder of fruits of Piper attenuatum (Buch-Ham) was subjected to maceration to prepare various extracts using different solvents in the order of increasing polarity. In vitro antiproliferative activity of all the extract was carried out using MTT assay against MDA-MB-231(Breast cancer) cell line. The Chloroform and Methanol extracts were found to be the most active fractions. The results from MTT assay of isolated compounds from Chloroform extract, NP7C was found to be the most potent antiproliferative agent with IC50 value of 3.83 ?M which is comparable to etoposide 2.37 ?M. Compound NP7L also exhibit significant antiproliferative activity (IC50 of 6.44 ?M) which was comparable to colchicine (IC50 = 6.3 ?M). Thus, the present study indicated that isolated compounds of Piper attenuatum (Buch-Ham) possess great potential to be developed as anticancer agent in future.en_US
dc.identifier.accessionnoT00748
dc.identifier.citationPathak,Neha (2018) Antiproliferative Activity of Chloroform and Methanol Extracts of Piper attenuatum (Buch-Ham)en_US
dc.identifier.urihttp://10.2.3.109/handle/32116/1937
dc.language.isoen_USen_US
dc.publisherCentral University of Punjaben_US
dc.subjectPiper attenuatumen_US
dc.subjectPiper speciesen_US
dc.subjectCanceren_US
dc.subjectAntiproliferativeen_US
dc.titleAntiproliferative Activity of Chloroform and Methanol Extracts of Piper attenuatum (Buch-Ham)en_US
dc.typeMaster Dissertationen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
T00748.pdf
Size:
2.15 MB
Format:
Adobe Portable Document Format
Download

Collections

Pharmaceutical Sciences and Natural Products - Master Dissertation
Master's Dissertations