Role of ZBTB7A zinc finger in tumorigenesis and metastasis

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dc.contributor.authorSingh, Atul Kumar
dc.contributor.authorVerma, Shiv
dc.contributor.authorKushwaha, Prem Prakash
dc.contributor.authorPrajapati, Kumari Sunita
dc.contributor.authorShuaib, Mohd
dc.contributor.authorKumar, Shashank
dc.contributor.authorGupta, Sanjay
dc.date.accessioned2024-01-16T14:23:08Z
dc.date.accessioned2024-08-13T10:34:06Z
dc.date.available2024-01-16T14:23:08Z
dc.date.available2024-08-13T10:34:06Z
dc.date.issued2021-05-20T00:00:00
dc.description.abstractThe zinc finger and BTB (broad-complex, tramtrack and bric a brac) domain containing protein 7A (ZBTB7A) is a pleiotropic transcription factor that plays an important role in various stages of cell proliferation, differentiation, and other developmental processes. ZBTB7A is a member of the POK family that directly and specifically binds to short DNA recognition sites located near their target genes thereby acting as transcriptional activator or repressor. ZBTB7A overexpression has been associated with tumorigenesis and metastasis in various human cancer types, including breast, prostate, lung, ovarian, and colon cancer. However in some instances downregulation of ZBTB7A results in tumor progression, suggesting its role as a tumor suppressor. ZBTB7A is involved with complicated regulatory networks which include protein�protein and protein-nucleic acid interactions. ZBTB7A involvement in cancer progression and metastasis is perhaps enabled through the regulation of various signaling pathways depending on the type and genetic context of cancer. The association of ZBTB7A with other proteins affects cancer aggressiveness, therapeutic resistance and clinical outcome. This review focuses on the involvement of ZBTB7A in various signaling pathways and its role in cancer progression. We will also review the literature on ZBTB7A and cancer which could be potentially explored for its therapeutic implications. � 2021, The Author(s), under exclusive licence to Springer Nature B.V.en_US
dc.identifier.doi10.1007/s11033-021-06405-x
dc.identifier.issn3014851
dc.identifier.urihttps://doi.org/10.1007/s11033-021-06405-x
dc.identifier.urihttp://10.2.3.109/handle/32116/2849
dc.language.isoen_USen_US
dc.publisherSpringer Science and Business Media B.V.en_US
dc.subjectBTB domainen_US
dc.subjectHuman canceren_US
dc.subjectTherapeutic resistanceen_US
dc.subjectTranscription factoren_US
dc.subjectZBTB7Aen_US
dc.subjectZinc fingeren_US
dc.titleRole of ZBTB7A zinc finger in tumorigenesis and metastasisen_US
dc.title.journalMolecular Biology Reportsen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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