Diabetic Neuropathy: A Repercussion of Vitamin D Deficiency

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dc.contributor.authorSharma, Prerna
dc.contributor.authorRani, Nidhi
dc.contributor.authorGangwar, Aishwarya
dc.contributor.authorSingh, Randhir
dc.contributor.authorKaur, Rajwinder
dc.contributor.authorUpadhyaya, Kumud
dc.date.accessioned2024-01-21T10:55:05Z
dc.date.accessioned2024-08-14T07:44:21Z
dc.date.available2024-01-21T10:55:05Z
dc.date.available2024-08-14T07:44:21Z
dc.date.issued2022-08-18T00:00:00
dc.description.abstractDiabetes mellitus is a crucial health issue worldwide. The worldwide ubiquity is 8.8% among adults, which is predicted to rise to 10.4% by 2040. Diabetic neuropathy is a long-term complication associated with the diabetes mellitus condition, which primarily targets Schwann cells, peripheral axons and cell bodies (perikarya) in DRG (dorsal root ganglia). It can be accom-panied by different factors such as metabolic factors such as insulin resistance, hypertension, obe-sity, low HDL level, and hypertriglyceridemia. The etiology of DPN is multifactorial. It is caused by hyperglycemia, micro-angiopathy, HbA1c, duration of diabetes, smoking status, high-density lipoprotein cholesterol and hypertension. Also, increased glucose conditions decrease vitamin D levels. Vitamin D, which is involved in neurotrophins such as NGF (nerve growth factor) and NCH (neuronal calcium homeostasis), plays a neuroprotective role in peripheral nerves. Depletionleads to vitamin D deficiency which further develops peripheral neuropathy in diabetic patients. Accu-mulation of AGEs (advanced glycation end product) plays a significant role in the pathogenesis of sensory neuronal damage. It contributes to microangiopathy and endoneurial vascular dysfunction in peripheral nerves. With vitamin D supplementation, the neuropathy pain scores were improved. � 2023 Bentham Science Publishers.en_US
dc.identifier.doi10.2174/1573399819666220817121551
dc.identifier.issn15733998
dc.identifier.urihttp://10.2.3.109/handle/32116/4332
dc.identifier.urlhttps://www.eurekaselect.com/207592/article
dc.language.isoen_USen_US
dc.publisherBentham Science Publishersen_US
dc.subjectcholecalciferolen_US
dc.subjectDiabetesen_US
dc.subjectdiabetic neuropathyen_US
dc.subjectHbA1cen_US
dc.subjecthyperglycemiaen_US
dc.subjectvitamin D deficiencyen_US
dc.titleDiabetic Neuropathy: A Repercussion of Vitamin D Deficiencyen_US
dc.title.journalCurrent Diabetes Reviewsen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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