Medicinal chemistry perspective of pyrido[2,3-d]pyrimidines as anticancer agents

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dc.contributor.authorKumar, Adarsh
dc.contributor.authorBhagat, Kuber Kumar
dc.contributor.authorSingh, Ankit Kumar
dc.contributor.authorSingh, Harshwardhan
dc.contributor.authorAngre, Tanuja
dc.contributor.authorVerma, Amita
dc.contributor.authorKhalilullah, Habibullah
dc.contributor.authorJaremko, Mariusz
dc.contributor.authorEmwas, Abdul-Hamid
dc.contributor.authorKumar, Pradeep
dc.date.accessioned2024-01-21T10:38:32Z
dc.date.accessioned2024-08-13T12:05:28Z
dc.date.available2024-01-21T10:38:32Z
dc.date.available2024-08-13T12:05:28Z
dc.date.issued2023-03-03T00:00:00
dc.description.abstractCancer is a major cause of deaths across the globe due to chemoresistance and lack of selective chemotherapy. Pyrido[2,3-d]pyrimidine is an emerging scaffold in medicinal chemistry having a broad spectrum of activities, including antitumor, antibacterial, CNS depressive, anticonvulsant, and antipyretic activities. In this study, we have covered different cancer targets, including tyrosine kinase, extracellular regulated protein kinases - ABL kinase, phosphatidylinositol-3 kinase, mammalian target of rapamycin, p38 mitogen-activated protein kinases, BCR-ABL, dihydrofolate reductase, cyclin-dependent kinase, phosphodiesterase, KRAS and fibroblast growth factor receptors, their signaling pathways, mechanism of action and structure-activity relationship of pyrido[2,3-d]pyrimidine derivatives as inhibitors of the above-mentioned targets. This review will represent the complete medicinal and pharmacological profile of pyrido[2,3-d]pyrimidines as anticancer agents, and will help scientists to design new selective, effective and safe anticancer agents. � 2023 The Royal Society of Chemistry.en_US
dc.identifier.doi10.1039/d3ra00056g
dc.identifier.issn20462069
dc.identifier.urihttp://10.2.3.109/handle/32116/3595
dc.identifier.urlhttp://xlink.rsc.org/?DOI=D3RA00056G
dc.language.isoen_USen_US
dc.publisherRoyal Society of Chemistryen_US
dc.subjectAmino acidsen_US
dc.subjectAromatic compoundsen_US
dc.subjectCell cultureen_US
dc.subjectDiseasesen_US
dc.subjectDrug productsen_US
dc.subjectMammalsen_US
dc.subjectAnti-cancer agentsen_US
dc.subjectAnti-tumorsen_US
dc.subjectAntibacterialsen_US
dc.subjectAnticonvulsant activityen_US
dc.subjectAntipyretic activitiesen_US
dc.subjectBroad spectrumen_US
dc.subjectCauses of deathen_US
dc.subjectChemoresistanceen_US
dc.subjectMedicinal chemistryen_US
dc.subjectTyrosine kinaseen_US
dc.subjectChemotherapyen_US
dc.titleMedicinal chemistry perspective of pyrido[2,3-d]pyrimidines as anticancer agentsen_US
dc.title.journalRSC Advancesen_US
dc.typeReviewen_US
dc.type.accesstypeOpen Accessen_US

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