Overview: Impact of Hydrogen Sulphide on Some Advanced Molecular Modulators Involved in Cardiac Hypertrophy

Abstract

Pressure overload (aortic stenosis) induced myocardial hypertrophy is allied with a poor prognosis in humans. It leads to the development of cardiac arrhythmias, diastolic dysfunction, and ultimately congestive heart failure. Heart failure is a global pandemic disease, affecting an estimated 26 million people worldwide and more than 4 million in India. This poses a huge burden to both individuals and society. However, there is limited knowledge regarding the underlying molecular mechanisms. Therefore, we hypothesized that the various cellular signaling pathway is playing a key role in myocardial hypertrophy. In this review, we were highlighting that drug-like H2S can target these cellular signaling pathways and hold promise as a potential lead for therapeutic intervention. Furthermore, it includes the concerns associated with H2S based therapy. In literature, clinical trials suggest that H2S based therapy is beneficial in cardiac hypertrophy and other diseases. The realization of the biological importance of H2S in numerous cells, tissues, and organs is now shedding light on the pathogenesis of various human diseases and paving the way for innovative therapeutic interventions. � 2022 University of Stockholm. All rights reserved.