Amino Acid Derived Prodrugs: An Approach to Improve the Bioavailability of Clinically Approved Drugs

Simple item page
dc.contributor.authorSingh, Yogesh
dc.contributor.authorSaklani, Samriti
dc.contributor.authorTantra, Tanmoy
dc.contributor.authorThareja, Suresh
dc.date.accessioned2024-01-21T10:38:17Z
dc.date.accessioned2024-08-13T12:05:12Z
dc.date.available2024-01-21T10:38:17Z
dc.date.available2024-08-13T12:05:12Z
dc.date.issued2021-06-04T00:00:00
dc.description.abstractAmino acids derived prodrugs emerged as an attractive approach to improve oral delivery of drugs with low solubility and permeability. Conjugation of amino acids with parent drug molecules resulted in several-fold increases in water solubility. Acceptability of the amino acids derived prodrug approach increases day by day to fulfill the different characteristics needed to get the desired pharmacological or therapeutic activity. Due to the significant structural diversity of amino acids, various amino acids can be employed as a carrier to provide desirable Pharmacokinetic-Phar-macodynamic (PK-PD) characteristics. The present review focused on using amino acids as a carrier moiety to improve approved drugs' bioavailability. Attempts have been made to cover amino acid conjugated clinically available drugs. � 2021 Bentham Science Publishers.en_US
dc.identifier.doi10.2174/1568026621666210602154438
dc.identifier.issn15680266
dc.identifier.urihttp://10.2.3.109/handle/32116/3519
dc.identifier.urlhttps://www.eurekaselect.com/193796/article
dc.language.isoen_USen_US
dc.publisherBentham Science Publishersen_US
dc.subjectADRen_US
dc.subjectAmino aciden_US
dc.subjectBioavailabilityen_US
dc.subjectPDen_US
dc.subjectPKen_US
dc.subjectProdrugen_US
dc.subjectSolubilityen_US
dc.titleAmino Acid Derived Prodrugs: An Approach to Improve the Bioavailability of Clinically Approved Drugsen_US
dc.title.journalCurrent Topics in Medicinal Chemistryen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

Files

Collections

Pharmaceutical Sciences and Natural Products - Research Publications