Comparative transcriptome profiling reveals the reprogramming of gene networks under arsenic stress in Indian mustard.

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dc.contributor.authorThakur, Sapna
dc.contributor.authorChoudhary, Shruti
dc.contributor.authorDubey, Preeti
dc.contributor.authorBhardwaj, Pankaj
dc.date.accessioned2019-10-23T05:22:47Z
dc.date.accessioned2024-08-13T11:02:40Z
dc.date.available2019-10-23T05:22:47Z
dc.date.available2024-08-13T11:02:40Z
dc.date.issued2019
dc.description.abstractArsenic is a widespread toxic metalloid that is classified as a class I carcinogen known to cause adverse health effects in humans. In the present study, we investigated arsenic accumulation potential and comparative gene expression in Indian mustard. The amount of arsenic accumulated in shoots varied in the range of 15.99-1138.70 mg/kg on a dry weight basis among five cultivars. Comparative expression analysis revealed 10?870 significantly differentially expressed genes mostly belonging to response to stress, metabolic processes, signal transduction, transporter activity, and transcription regulator activity to be up-regulated, while most of the genes involved in photosynthesis, developmental processes, and cell growth were found to be down-regulated in arsenic-treated tissues. Further, pathway analysis using the KEGG Automated Annotation server (KAAS) revealed a large-scale reprogramming of genes involved in genetic and environmental information processing pathways. Top pathways with maximum KEGG orthology hits included carbon metabolism (2.5%), biosynthesis of amino acids (2.1%), plant hormone signal transduction (1.4%), and glutathione metabolism (0.6%). A transcriptomic investigation to understand the arsenic accumulation and detoxification in Indian mustard will not only help to improve its phytoremediation efficiency but also add to the control measures required to check bioaccumulation of arsenic in the food chain.en_US
dc.identifier.doi10.1139/gen-2018-0152
dc.identifier.urihttp://10.2.3.109/handle/32116/2490
dc.identifier.urlhttps://www.nrcresearchpress.com/doi/pdf/10.1139/gen-2018-0152
dc.language.isoenen_US
dc.publisherCanadian Science Publishingen_US
dc.subjectarsenicen_US
dc.subjectBrassica junceaen_US
dc.subjectphytoremediationen_US
dc.subjecttranscriptomeen_US
dc.subjectpathway analysisen_US
dc.titleComparative transcriptome profiling reveals the reprogramming of gene networks under arsenic stress in Indian mustard.en_US
dc.title.journalGenomeen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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