DABCO Mediated Sulfur Activation-Intramolecular De-Nitration Strategy for the Synthesis of Novel Dihydrothiochromeno[4,3-c]pyrazoles

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dc.contributor.authorDeepika
dc.contributor.authorPaul, Avijit K.
dc.contributor.authorMalakar, Chandi C.
dc.contributor.authorBansal, Ajay
dc.contributor.authorSingh, Virender
dc.date.accessioned2024-01-21T10:33:10Z
dc.date.accessioned2024-08-13T11:16:21Z
dc.date.available2024-01-21T10:33:10Z
dc.date.available2024-08-13T11:16:21Z
dc.date.issued2023-07-24T00:00:00
dc.description.abstractA facile and highly efficient metal-free approach has been unfolded for the synthesis of novel dihydrothiochromeno[4,3-c]pyrazoles using elemental sulfur as a powerful sulfurating reagent. This method includes sp2 C?H functionalization followed by sp2 C?NO2 group displacement using elemental sulfur as an odourless sulfur source activated by DABCO in DMSO. Using the developed synthetic strategy, a library of 29 novel dihydrothiochromeno[4,3-c]pyrazoles, incorporating two pharmacologically important scaffolds has been synthesized in 52�76% yield with a broad substrate scope. A sensible mechanistic proposal has been projected based on control experiments. � 2023 Wiley-VCH GmbH.en_US
dc.identifier.doi10.1002/ajoc.202300289
dc.identifier.issn21935807
dc.identifier.urihttp://10.2.3.109/handle/32116/3283
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/ajoc.202300289
dc.language.isoen_USen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.subjectde-nitrationen_US
dc.subjectelemental sulfuren_US
dc.subjectnitrochalconeen_US
dc.subjectpyrazole fused thiochromenesen_US
dc.subjectsulfur insertionen_US
dc.titleDABCO Mediated Sulfur Activation-Intramolecular De-Nitration Strategy for the Synthesis of Novel Dihydrothiochromeno[4,3-c]pyrazolesen_US
dc.title.journalAsian Journal of Organic Chemistryen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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