GNL3 and PA2G4 as Prognostic Biomarkers in Prostate Cancer

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dc.contributor.authorKumar, Shashank
dc.contributor.authorShuaib, Mohd
dc.contributor.authorAlAsmari, Abdullah F.
dc.contributor.authorAlqahtani, Faleh
dc.contributor.authorGupta, Sanjay
dc.date.accessioned2024-01-16T14:23:25Z
dc.date.accessioned2024-08-13T10:34:18Z
dc.date.available2024-01-16T14:23:25Z
dc.date.available2024-08-13T10:34:18Z
dc.date.issued2023-05-12T00:00:00
dc.description.abstractProstate cancer is a multifocal and heterogeneous disease common in males and remains the fifth leading cause of cancer-related deaths worldwide. The prognosis of prostate cancer is variable and based on the degree of cancer and its stage at the time of diagnosis. Existing biomarkers for the prognosis of prostate cancer are unreliable and lacks specificity and sensitivity in guiding clinical decision. There is need to search for novel biomarkers having prognostic and predictive capabilities in guiding clinical outcomes. Using a bioinformatics approach, we predicted GNL3 and PA2G4 as biomarkers of prognostic significance in prostate cancer. A progressive increase in the expression of GNL3 and PA2G4 was observed during cancer progression having significant association with poor survival in prostate cancer patients. The Receiver Operating Characteristics of both genes showed improved area under the curve against sensitivity versus specificity in the pooled samples from three different GSE datasets. Overall, our analysis predicted GNL3 and PA2G4 as prognostic biomarkers of clinical significance in prostate cancer. � 2023 by the authors.en_US
dc.identifier.doi10.3390/cancers15102723
dc.identifier.issn20726694
dc.identifier.urihttps://doi.org/10.3390/cancers15102723
dc.identifier.urihttp://10.2.3.109/handle/32116/2929
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.subjectbiomarkersen_US
dc.subjectoverall survivalen_US
dc.subjectprognosticsen_US
dc.subjectprostate canceren_US
dc.subjectTCGA databaseen_US
dc.titleGNL3 and PA2G4 as Prognostic Biomarkers in Prostate Canceren_US
dc.title.journalCancersen_US
dc.typeReviewen_US
dc.type.accesstypeOpen Accessen_US

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