Mitochondria-targeted drug delivery systems for the effective treatment of neurodegenerative disorders

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dc.contributor.authorKhare, Vaishali
dc.contributor.authorGupta, Surbhi
dc.contributor.authorBisht, Preeti
dc.contributor.authorGarabadu, Debapriya
dc.date.accessioned2024-01-21T10:55:01Z
dc.date.accessioned2024-08-14T07:44:18Z
dc.date.available2024-01-21T10:55:01Z
dc.date.available2024-08-14T07:44:18Z
dc.date.issued2022-03-18T00:00:00
dc.description.abstractMitochondria are known to be the powerhouse of the cell. Its dysfunction leads to several alterations in cellular physiology. Mitochondrial dysfunction is a well-documented process in the pathophysiology of neurodegeneration and neurodegenerative disorders. The interplay between mitochondrial dysfunction and oxidative stress is well suggested in the pathophysiology of neurodegenerative disorders. The activation of autophagy is also well established along with the mitochondrial impairment in neurodegenerative disorders. The relationship between mitochondrial dysfunction and excitotoxicity is also well established in the pathophysiology of neurodegenerative disorders. Enhanced apoptosis and necrosis is well established along with mitochondrial dysfunction in the pathophysiology of neurodegenerative disorders. Several synthetic and herbal drugs have been established in the management of mitochondrial dysfunction-induced neurodegenerative disorders. Little information is available about the formulations of the established mitochondria-targeted drugs in the management of neurodegenerative disorders. Therefore, critical attention is required in the development of mitochondria-targeted drug delivery systems for therapeutic and diagnostic applications in neurodegenerative disorders. � 2022 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/B978-0-323-85544-0.00013-7
dc.identifier.isbn9780323855440
dc.identifier.isbn9780323898010
dc.identifier.urihttp://10.2.3.109/handle/32116/4311
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/B9780323855440000137
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectApoptosisen_US
dc.subjectDrug delivery systemen_US
dc.subjectExcitotoxicityen_US
dc.subjectMitochondriaen_US
dc.subjectNecrosisen_US
dc.subjectNeurodegenerative disorderen_US
dc.titleMitochondria-targeted drug delivery systems for the effective treatment of neurodegenerative disordersen_US
dc.title.journalNanomedical Drug Delivery for Neurodegenerative Diseasesen_US
dc.typeBook chapteren_US
dc.type.accesstypeClosed Accessen_US

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