Various Cellular and Molecular Axis Involved in the Pathogenesis of Asthma

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dc.contributor.authorBhatti, Gurjit Kaur
dc.contributor.authorKhurana, Amit
dc.contributor.authorGarabadu, Debapriya
dc.contributor.authorGupta, Prashant
dc.contributor.authorJawalekar, Snehal Sainath
dc.contributor.authorBhatti, Jasvinder Singh
dc.contributor.authorNavik, Umashanker
dc.date.accessioned2024-01-21T10:54:58Z
dc.date.accessioned2024-08-14T07:44:16Z
dc.date.available2024-01-21T10:54:58Z
dc.date.available2024-08-14T07:44:16Z
dc.date.issued2021-07-02T00:00:00
dc.description.abstractAsthma is a chronic inflammatory disease described by impaired lung function, airway hyperresponsiveness, episodic wheezing, and dyspnea. Asthma prevalence has risen drastically, and it is estimated that more than 339 million individuals worldwide had asthma with marked heterogeneity in pathophysiology and etiology. Several factors involved in the progression and development of asthma include allergens, pollutants, obesity, viruses, antigens, and many more, eliciting strong inflammatory and immune responses, causing airflow obstruction, and tightening of respiratory smooth muscle causing the characteristic asthma symptoms. Multiple complex molecular pathways are involved in asthma pathophysiologies such as immunoglobulin E, cytokines, nitric oxide, dendritic cells, leukotrienes, oxidative stress, and inflammatory infiltrate of mast cells, neutrophils, eosinophils, lymphocytes, innate immunity, and many more. The current chapter focuses on illustrating the various molecular pathways that contribute to asthma development and its progression. � The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021.en_US
dc.identifier.doi10.1007/978-981-33-6827-9_3
dc.identifier.isbn9789813368279
dc.identifier.isbn9789813368262
dc.identifier.urihttp://10.2.3.109/handle/32116/4293
dc.identifier.urlhttps://link.springer.com/10.1007/978-981-33-6827-9_3
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.subjectAirway hyperresponsivenessen_US
dc.subjectAsthmaen_US
dc.subjectCytokinesen_US
dc.subjectImmunityen_US
dc.subjectInflammationen_US
dc.titleVarious Cellular and Molecular Axis Involved in the Pathogenesis of Asthmaen_US
dc.title.journalTargeting Cellular Signalling Pathways in Lung Diseasesen_US
dc.typeBook chapteren_US
dc.type.accesstypeClosed Accessen_US

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