Copper catalysed regioselective synthesis of pyrimidine substituted Indolizino[8,7-b]indole derivatives via cascade A3 annulation

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dc.contributor.authorKumar, Sunit
dc.contributor.authorKumar, Rakesh
dc.contributor.authorMalakar, Chandi C.
dc.contributor.authorSingh, Virender
dc.date.accessioned2024-01-21T10:33:09Z
dc.date.accessioned2024-08-13T11:16:21Z
dc.date.available2024-01-21T10:33:09Z
dc.date.available2024-08-13T11:16:21Z
dc.date.issued2023-07-08T00:00:00
dc.description.abstractCu(II) salt has been found to be an efficient catalyst for the regioselective synthesis of a series of novel indolizino [8,7-b]indole derivatives with pyrimidine tethers via three-component annulation of 1-formyl-9H-?-carbolines (Kumujian C), 2-amino-pyrimidines and terminal alkynes. The reactions proceeds through Cu-catalysed A3-coupling followed by intramolecular cyclisation in a cascade manner. The scope of strategy has been exemplified with a library of biologically interesting 25 indolizino [8,7-b]indoles with pyrimidine tethers which mimics several natural products. � 2023 Elsevier Ltden_US
dc.identifier.doi10.1016/j.tet.2023.133547
dc.identifier.issn404020
dc.identifier.urihttp://10.2.3.109/handle/32116/3279
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0040402023003496
dc.language.isoen_USen_US
dc.publisherElsevier Ltden_US
dc.subjectA<sup>3</sup>-couplingen_US
dc.subjectCooperative catalysisen_US
dc.subjectIndolizino[8,7-b]indoleen_US
dc.subjectPyrimidineen_US
dc.subject?-Carbolineen_US
dc.titleCopper catalysed regioselective synthesis of pyrimidine substituted Indolizino[8,7-b]indole derivatives via cascade A3 annulationen_US
dc.title.journalTetrahedronen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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