Dihydropyrimidinone scaffold and potential therapeutic targets

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dc.contributor.authorKumar, Adarsh
dc.contributor.authorSingh, Ankit Kumar
dc.contributor.authorVijayan, Veena
dc.contributor.authorSingh, Harshwardhan
dc.contributor.authorVerma, Amita
dc.contributor.authorKumar, Pradeep
dc.date.accessioned2024-01-21T10:38:37Z
dc.date.accessioned2024-08-13T12:05:34Z
dc.date.available2024-01-21T10:38:37Z
dc.date.available2024-08-13T12:05:34Z
dc.date.issued2023-08-25T00:00:00
dc.description.abstractDihydropyrimidine is the most important heterocyclic ring system involved in the synthesis of RNA and DNA. Dihydropyrimidines were produced synthetically by multicomponent reactions such as the Biginelli reaction. Because of their remarkable biological characteristics, dihydropyrimidinones (DHPMs) have drawn considerable attention in recent years. In this chapter, we have described the synthetic and pharmacological properties of DHPMs employing multicomponent synthesis. It emphasizes also widespread pharmaceutical applications of DHPMs, including antitubercular, antifilarial, antihypertensive, antiinflammatory, anticancer, antifungal, antibacterial, anti-HIV, antihyperglycemic, anti-SARS, analgesic, antioxidant, anticonvulsant, anti-Alzheimer�s and antihepatitis properties. This chapter will be of immense importance for the scientists working in this area. � 2023 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/B978-0-443-19094-0.00004-7
dc.identifier.isbn9780443190940
dc.identifier.isbn9780443153044
dc.identifier.urihttp://10.2.3.109/handle/32116/3616
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/B9780443190940000047
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectBiginelli reactionen_US
dc.subjectDihydropyrimidinonesen_US
dc.subjectpharmacological activityen_US
dc.subjectsynthesisen_US
dc.titleDihydropyrimidinone scaffold and potential therapeutic targetsen_US
dc.title.journalDihydropyrimidinones as Potent Anticancer Agents: Medicinal Chemistry Perspectiveen_US
dc.typeBook chapteren_US
dc.type.accesstypeClosed Accessen_US

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