Implications of vitamin D deficiency in systemic inflammation and cardiovascular health

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dc.contributor.authorDey, Sanjay Kumar
dc.contributor.authorKumar, Shashank
dc.contributor.authorRani, Diksha
dc.contributor.authorMaurya, Shashank Kumar
dc.contributor.authorBanerjee, Pratibha
dc.contributor.authorVerma, Madhur
dc.contributor.authorSenapati, Sabyasachi
dc.date.accessioned2024-01-16T14:23:26Z
dc.date.accessioned2024-08-13T10:34:19Z
dc.date.available2024-01-16T14:23:26Z
dc.date.available2024-08-13T10:34:19Z
dc.date.issued2023-06-24T00:00:00
dc.description.abstractClinical, epidemiological, and molecular studies have sufficiently highlighted the vitality of vitamin D [25(OH)D and 1,25(OH)2D] in human health and wellbeing. Globally, vitamin D deficiency (VDD) has become a public health concern among all age groups. There is a very high prevalence of VDD per the estimates from several epidemiological studies on different ethnic populations. But, population-specific scales do not support these estimates to define VDD clinically and consistent genetic associations. However, clinical studies have shown the relevance of serum vitamin D screening and oral supplementation in improving health conditions, pointing toward a more prominent role of vitamin D in health and wellness. Routinely, the serum concentration of vitamin D is measured to determine the deficiency and is correlated with physiological conditions and clinical symptoms. Recent research points toward a more inclusive role of vitamin D in different disease pathologies and is not just limited to otherwise bone health and overall growth. VDD contributes to the natural history of systemic ailments, including cardiovascular and systemic immune diseases. Considering its significant impact on premature morbidity and mortality, there is a compelling need to comprehensively review and document the direct and indirect implications of VDD in immune system deregulation, systemic inflammatory conditions, and cardio-metabolism. The recommendations from this review call for furthering our research concerning vitamin D and its direct and indirect implications. � 2023 Taylor & Francis Group, LLC.en_US
dc.identifier.doi10.1080/10408398.2023.2224880
dc.identifier.issn10408398
dc.identifier.urihttps://doi.org/10.1080/10408398.2023.2224880
dc.identifier.urihttp://10.2.3.109/handle/32116/2936
dc.language.isoen_USen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.subjectAutoimmunityen_US
dc.subjectCancersen_US
dc.subjectCardio-metabolismen_US
dc.subjectCardiovascular diseasesen_US
dc.subjectNeuroinflammationen_US
dc.subjectPublic healthen_US
dc.subjectSystemic inflammationen_US
dc.subjectVitamin D deficiencyen_US
dc.titleImplications of vitamin D deficiency in systemic inflammation and cardiovascular healthen_US
dc.title.journalCritical Reviews in Food Science and Nutritionen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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Biochemistry And Microbial Sciences - Research Publications