STAT signaling as a target for intervention: from cancer inflammation and angiogenesis to non-coding RNAs modulation

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dc.contributor.authorTuli, Hardeep Singh
dc.contributor.authorSak, Katrin
dc.contributor.authorIqubal, Ashif
dc.contributor.authorGarg, Vivek Kumar
dc.contributor.authorVarol, Mehmet
dc.contributor.authorSharma, Uttam
dc.contributor.authorChauhan, Abhishek
dc.contributor.authorYerer, Mukerrem Betul
dc.contributor.authorDhama, Kuldeep
dc.contributor.authorJain, Manju
dc.contributor.authorJain, Aklank
dc.date.accessioned2024-01-16T14:23:13Z
dc.date.accessioned2024-08-13T10:34:10Z
dc.date.available2024-01-16T14:23:13Z
dc.date.available2024-08-13T10:34:10Z
dc.date.issued2022-04-26T00:00:00
dc.description.abstractAs a landmark, scientific investigation in cytokine signaling and interferon-related anti-viral activity, signal transducer and activator of transcription (STAT) family of proteins was first discovered in the 1990s. Today, we know that the STAT family consists of several transcription factors which regulate various molecular and cellular processes, including proliferation, angiogenesis, and differentiation in human carcinoma. STAT family members play an active role in transducing signals from cell membrane to nucleus through intracellular signaling and thus activating gene transcription. Additionally, they are also associated with the development and progression of human cancer by facilitating inflammation, cell survival, and resistance to therapeutic responses. Accumulating evidence suggests that not all STAT proteins are associated with the progression of human malignancy; however, STAT3/5 are constitutively activated in various cancers, including multiple myeloma, lymphoma, breast cancer, prostate hepatocellular carcinoma, and non-small cell lung cancer. The present review highlights how STAT-associated events are implicated in cancer inflammation, angiogenesis and non-coding RNA (ncRNA) modulation to highlight potential intervention into carcinogenesis-related cellular processes. � 2022, The Author(s), under exclusive licence to Springer Nature B.V.en_US
dc.identifier.doi10.1007/s11033-022-07399-w
dc.identifier.issn3014851
dc.identifier.urihttps://doi.org/10.1007/s11033-022-07399-w
dc.identifier.urihttp://10.2.3.109/handle/32116/2875
dc.language.isoen_USen_US
dc.publisherSpringer Science and Business Media B.V.en_US
dc.subjectAngiogenesisen_US
dc.subjectChemoresistanceen_US
dc.subjectInflammationen_US
dc.subjectncRNAen_US
dc.subjectSTATen_US
dc.subjectTherapeuticsen_US
dc.titleSTAT signaling as a target for intervention: from cancer inflammation and angiogenesis to non-coding RNAs modulationen_US
dc.title.journalMolecular Biology Reportsen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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