Neuroprotective potential of Moringa oleifera mediated by NF-kB/Nrf2/HO-1 signaling pathway: A review

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dc.contributor.authorMundkar, Maroti
dc.contributor.authorBijalwan, Anjali
dc.contributor.authorSoni, Divya
dc.contributor.authorKumar, Puneet
dc.date.accessioned2024-01-21T10:55:06Z
dc.date.accessioned2024-08-14T07:44:21Z
dc.date.available2024-01-21T10:55:06Z
dc.date.available2024-08-14T07:44:21Z
dc.date.issued2022-10-07T00:00:00
dc.description.abstractMoringa oleifera is a traditional Indian herb belonging to the Moringaceae family, it is commonly known as the horse-radish tree, drumstick, or sahajna. In developing countries, Moringa is used as feed for both humans and animals due to its well-known antioxidant, anti-inflammatory, and anti-apoptotic properties owing to its several phytoconstituents including ?-carotene, quercetin, kaempferol, ascorbic acid, flavonoids, phenolic acid, rhamnose, glycosylates, glucomoringin, and isothiocyanates. These constituents help to maintain the brain antioxidant enzyme levels, mitochondrial functions, and neurogenesis, showing neuroprotective effects in several neurodegenerative disorders including Parkinson's Disease, Alzheimer's Disease, Huntington's Disease, and Amyotrophic lateral sclerosis. This review discusses various phytoconstituent of moringa and their therapeutic potential in various neurological disorders. Additionally, we also concise the safety and toxicity profile, of different molecular pathways involved in the neuroprotective effect of M. oleifera including M. oleifera nanoparticles for better therapeutic value. Practical applications: Several clinical and preclinical studies on Moringa oleifera have been conducted, and the outcomes indicate moringa could be used in the treatment of brain disorders. As a result, we conclude that moringa and its nanoformulations could be employed to treat neurological problems. In the future, M. oleifera phytoconstituents could be evaluated against specific signaling pathways, which could aid researchers in discovering their mechanism of action. Furthermore, the use of moringa as a nutraceutical owing to its myriad pharmacological potential will go a long way in boosting the economy of countries that grow moringa on a large scale. � 2022 Wiley Periodicals LLC.en_US
dc.identifier.doi10.1111/jfbc.14451
dc.identifier.issn1458884
dc.identifier.urihttp://10.2.3.109/handle/32116/4340
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1111/jfbc.14451
dc.language.isoen_USen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.subjectanti-inflammatoryen_US
dc.subjectantioxidantsen_US
dc.subjectmitochondrial dysfunctionen_US
dc.subjectMoringa oleiferaen_US
dc.subjectneurodegenerative disordersen_US
dc.subjectneuroprotectionen_US
dc.titleNeuroprotective potential of Moringa oleifera mediated by NF-kB/Nrf2/HO-1 signaling pathway: A reviewen_US
dc.title.journalJournal of Food Biochemistryen_US
dc.typeReviewen_US
dc.type.accesstypeOpen Accessen_US

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