Dual Aromatase-Sulphatase Inhibitors (DASIs) for the Treatment of Hormone Dependent Breast Cancer

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dc.contributor.authorBanjare, Laxmi
dc.contributor.authorJain, Akhlesh Kumar
dc.contributor.authorThareja, Suresh
dc.date.accessioned2024-01-21T10:38:15Z
dc.date.accessioned2024-08-13T12:05:10Z
dc.date.available2024-01-21T10:38:15Z
dc.date.available2024-08-13T12:05:10Z
dc.date.issued2021-01-19T00:00:00
dc.description.abstractBreast cancer is the most frequently diagnosed cancer in women and the second most common form of cancer, causing death after lung cancer, all across the globe at an alarming rate. The level of estrogens in breast cancer tissues of postmenopausal women is 10-40 folds higher than the non-carcinogenic breast tissues. As a result of this greater level of estrogen, breast tissue becomes more prone to develop breast cancer; mainly, estradiol plays a significant role in the initiation and development of hormone-dependent breast cancer. Androstenedione, Adrenal dehydroepiandrosterone sulfate, and estrone-sulfate also play an important role as precursors for estrogen biosynthesis. Estrogen deprivation exhibits an attractive phenomenon in the advancement of ideal therapeutics for the treatment of breast cancer. Inhibition of aromatase and sulphatase emerged as an attractive therapy for the treatment of hormone-dependent breast cancer via deprivation of estrogen by different pathways. The cocktail of aromatase and sulphatase inhibitors known as Dual Aromatase-sulphatase Inhibitors (DASIs) emerged as an attractive approach for effective estrogen deprivation. The present review arti-cle focused on the journey of dual aromatase-sulphatase inhibitors from the beginning to date (2020). Keeping in view the key observations, this review may be helpful for medicinal chemists to design and develop new and efficient dual aromatase-sulphatase inhibitors for the possible treatment of hor-mone-related breast cancer. � 2021 Bentham Science Publishers.en_US
dc.identifier.doi10.2174/1389557521666210119123840
dc.identifier.issn13895575
dc.identifier.urihttp://10.2.3.109/handle/32116/3507
dc.identifier.urlhttp://www.eurekaselect.com/190447/article
dc.language.isoen_USen_US
dc.publisherBentham Science Publishersen_US
dc.subjectAnticancer agentsen_US
dc.subjectAromatase inhibitorsen_US
dc.subjectDual inhibitorsen_US
dc.subjectEstrogenen_US
dc.subjectHormone-dependent breast canceren_US
dc.subjectSulphatase inhibitorsen_US
dc.titleDual Aromatase-Sulphatase Inhibitors (DASIs) for the Treatment of Hormone Dependent Breast Canceren_US
dc.title.journalMini-Reviews in Medicinal Chemistryen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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