Identifying novel miRNA targets of anticancer drugs in normoxic and hypoxic condition

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dc.contributor.authorGoyal, Sapna
dc.contributor.supervisorSingh, Sandeep
dc.date.accessioned2018-08-31T04:13:44Z
dc.date.accessioned2024-08-14T07:04:10Z
dc.date.available2018-08-31T04:13:44Z
dc.date.available2024-08-14T07:04:10Z
dc.date.issued2018
dc.description.abstractBreast cancer has become the prevailing cause of death, so the research for their treatment has become advanced day by day. Breast cancer behaves differently in normoxic and hypoxic condition so does the anticancer drugs in both the condition in order to treat them. These drugs might have different effect on the expression of miRNAs in both normoxic and hypoxic conditions. In the present study, we evaluated the IC50 of three anticancer drugs-doxorubicin, ?-Amanitin, DCA on MDA-MB-231 and after treatment with these drugs, have checked the expression of miRNAs- let-7b and miR1275 in both hypoxic and normoxic condition by RT-PCR and results were analyzed by native PAGEen_US
dc.identifier.accessionnoT00629
dc.identifier.citationGOYAL, SAPNA (2018) Identifying novel miRNA targets of anticancer drugs in normoxic and hypoxic conditionen_US
dc.identifier.urihttps://kr.cup.edu.in/handle/32116/1886
dc.language.isoen_USen_US
dc.publisherCentral University of Punjaben_US
dc.subjectmiRNAen_US
dc.subjectanticancer drugsen_US
dc.subjectnormoxic conditionen_US
dc.subjecthypoxic conditionen_US
dc.titleIdentifying novel miRNA targets of anticancer drugs in normoxic and hypoxic conditionen_US
dc.typeMaster Dissertationen_US

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