Recent advances for construction and late-stage diversification of indole core via C-H bond activation/functionalization

dc.contributor.authorSinha, Arun Kumar
dc.contributor.authorKumar, Rakesh
dc.date.accessioned2024-01-21T10:32:55Z
dc.date.accessioned2024-08-13T11:16:36Z
dc.date.available2024-01-21T10:32:55Z
dc.date.available2024-08-13T11:16:36Z
dc.date.issued2021-02-26T00:00:00
dc.description.abstractIndole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials. Owing to such a huge potential, continuous efforts are being put forward to construct or diversify this scaffold. This chapter provides an overview of various recently developed methodologies for the construction of indole core via C-H bond activation/functionalization. In particular, Pd- and Ru-mediated cyclization strategies involving Csp2-H functionalization of monofunctionalized arene substrates with the unsaturated bond of alkene and alkyne are highlighted herein. Also, late-stage diversification of indole system (C4-C7 position) via direct C-H activation is covered. Furthermore, the mechanistic aspects of some of these reactions are discussed as well. � 2021 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/B978-0-12-820586-0.00003-0
dc.identifier.isbn9780128205860
dc.identifier.urihttps://kr.cup.edu.in/handle/32116/3208
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/B9780128205860000030
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectC-H activationen_US
dc.subjectC-H functionalizationen_US
dc.subjectdirecting groupsen_US
dc.subjectheterocyclic compoundsen_US
dc.subjectIndoleen_US
dc.subjectlate-stage diversificationen_US
dc.subjecttransition- metalsen_US
dc.titleRecent advances for construction and late-stage diversification of indole core via C-H bond activation/functionalizationen_US
dc.title.journalGreen Synthetic Approaches for Biologically Relevant Heterocycles: Volume 1: Advanced Synthetic Techniquesen_US
dc.typeBook chapteren_US
dc.type.accesstypeClosed Accessen_US

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