Synthesis of pyrazolo[4,3-c]quinolines and the C-C bond cleavage during reductive cyclization

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dc.contributor.authorDevi, Nisha
dc.contributor.authorGupta, Antriksh
dc.contributor.authorGujjarappa, Raghuram
dc.contributor.authorMalakar, Chandi C.
dc.contributor.authorSingh, Virender
dc.date.accessioned2024-01-21T10:32:54Z
dc.date.accessioned2024-08-13T11:16:36Z
dc.date.available2024-01-21T10:32:54Z
dc.date.available2024-08-13T11:16:36Z
dc.date.issued2021-02-26T00:00:00
dc.description.abstractAn efficient synthesis of o-nitrophenyl tethered pyrazole-4-carbaldehydes was achieved via Vilsmeier-Haack formylation of hydrazone derivatives which were subjected to Claisen-Schmidt condensation and Morita-Baylis-Hillman (MBH) reaction with various methyl ketones and activated alkenes respectively to generate the corresponding chalcones and MBH adducts. However, successive Fe-mediated reductive cyclization was followed by an unusual C-C bond cleavage which afforded the pyrazolo[4,3-c]quinolines devoid of diverse substituents at C-4 position. � 2021 The Japan Institute of Heterocyclic Chemistry.en_US
dc.identifier.doi10.3987/COM-20-14403
dc.identifier.issn3855414
dc.identifier.urihttps://kr.cup.edu.in/handle/32116/3207
dc.identifier.urlhttp://www.heterocycles.jp/newlibrary/libraries/abst/27129
dc.language.isoen_USen_US
dc.publisherJapan Institute of Heterocyclic Chemistryen_US
dc.titleSynthesis of pyrazolo[4,3-c]quinolines and the C-C bond cleavage during reductive cyclizationen_US
dc.title.journalHeterocyclesen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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